MEGIN Masterclass

Multimodal MEG Fusion to Study Neurodegenerative Disorders

Presented by Alex Wiesman, PhD.

Abstract: “This Masterclass is presented by Alex Wiesman, postdoctoral fellow at the Montreal Neurological Institute. The webinar will discuss, Neurodegenerative disorders affect neurophysiological signalling, with implications for cognitive and motor abilities. While previous MEG research in patients with Alzheimer’s and Parkinson’s disease has suggested robust pathophysiological markers of disease status, the proteinopathic and neurochemical changes that shape these alterations in brain activity are not well understood. In this Masterclass, I will discuss our recent research linking MEG measures of cortical neurophysiology with PET- and MRI-derived measures of proteinopathy, neurotransmitter systems, and deep-brain nucleus integrity to understand the neurochemical bases of cortical pathophysiology in neurodegenerative disorders of aging. This work suggests that MEG represents a sensitive and repeatable tool for tracking clinically- and pathologically-relevant brain dynamics in patients with Alzheimer’s and Parkinson’s disease.”

Bio: Alex Wiesman is a CIHR Banting and NIH F32 postdoctoral fellow at the Montreal Neurological Institute, where he uses multimodal neuroimaging to study the proteinopathic and neurochemical bases of brain activity changes in patients with neurodegenerative disorders. His recent research has demonstrated a spatially-resolved shift of cortical rhythms towards slower patterns of signaling, which tracks the accumulation of proteinopathy and hallmark clinical outcomes in Alzheimer’s and Parkinson’s disease. Alex has published more than 70 peer-reviewed papers in leading journals using MEG.

*The MEGIN Masterclasses content and speakers selected are only for information purposes and MEGIN does not endorse any applications or treatments mentioned.

**TRIUX™ neo is intended to non-invasively record brain activity, and when interpreted by trained physicians, to help localize these active areas. All other applications are scientific research in nature. Please contact MEGIN for further information.