Page 282 - MEGIN Book Of Abstracts - 2023

Schizophrenia

Abnormal Information Flow in Schizophrenia Is neus to the medio-ventral occipital cortex was associ-
Linked to Psychosis (2022) ated with more severe clinical psychopathology (ie,
positive psychotic symptoms), while reduced informa-
Jia, Yingxin; Kudo, Kiwamu; Hinkley, Leighton B tion flow between insula and middle temporal gyrus
N; Fisher, Melissa; Vinogradov, Sophia; Nagarajan, was associated with worsening cognitive symptoms.
Srikantan; Subramaniam, Karuna
CONCLUSIONS The present findings highlight the
Department of Radiology and Biomedical Imaging, Uni- importance of delineating dysfunction in neural infor-
versity of California, San, Francisco, CA 94143, USA; Medical mation flow in specific oscillatory frequencies between
Imaging Business Center, Ricoh Company, Ltd., Kanazawa, distinct regions that underlie the cognitive and psy-
Japan; Department of Psychiatry, University of Minnesota, chotic symptoms in SZ, and provide potential neural
Minneapolis, MN 55454, USA; Department of Psychiatry, biomarkers that could lead to innovations in future
University of California, San Francisco, CA 94143, USA neuromodulation treatment development.

BACKGROUND AND HYPOTHESIS Prior research has Keywords: phase, psychotic symptoms, resting, state MEG,
shown that patients with schizophrenia (SZ) show dis- transfer entropy
ruption in brain network connectivity that is thought
to underlie their cognitive and psychotic symptoms. Schizophrenia bulletin (2022), Vol. 48, No. 6 (36073155) (0
However, most studies examining functional network citations)
disruption in schizophrenia have focused on the tem-
porally correlated coupling of the strength of network
connections. Here, we move beyond correlative metrics Neuronal imbalance of excitation and inhibition in
to assay causal computations of connectivity changes schizophrenia: a scoping review of gamma-band
in directed neural information flow, assayed from a ASSR findings (2022)
neural source to a target in SZ.
Onitsuka, Toshiaki; Tsuchimoto, Rikako; Oribe, Naoya;
STUDY DESIGN This study describes a whole-brain Spencer, Kevin M; Hirano, Yoji
magnetoencephalography-imaging approach to ex-
amine causal computations of connectivity changes in Department of Neuroimaging Psychiatry, Graduate School of
directed neural information flow between brain regions Medical Sciences, Kyushu University, Fukuoka, Japan; Depart-
during resting states, quantified by phase-transfer en- ment of Neuropsychiatry, Graduate School of Medical Sci-
tropy (PTE) metrics, assayed from a neural source to an ences, Kyushu University, Fukuoka, Japan; Division of Clinical
endpoint, in 21 SZ compared with 21 healthy controls Research, National Hospital Organization, Hizen Psychiatric
(HC), and associations with cognitive and clinical psy- Medical Center, Saga, Japan; Clinical Neuroscience Divi-
chotic symptoms in SZ. sion, Laboratory of Neuroscience, Department of Psychiatry,
Boston VA Healthcare System, Brockton Division and Harvard
STUDY RESULTS We found that SZ showed significant Medical School, Brockton, Massachusetts, USA
disruption in information flow in alpha (8-12 Hz) and
beta (12-30 Hz) frequencies, compared to HC. Reduced ABSTRACT Recent empirical findings suggest that
information flow in alpha frequencies from the precu- altered neural synchronization, which is hypothesized

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