Page 284 - MEGIN Book Of Abstracts - 2023

Keywords: First-episode psychosis, Functional connectiv- of self-similarity and multifractality values. Statistical
ity, Magnetoencephalography, Reality distortion, Visual tests showed that patients had higher values of self-
working memory similarity than controls in fronto-temporal regions,
indicative of more regularity and memory in the signal.
Journal of psychiatric research (2022), Vol. 153 (35820225) In contrast, patients had less multifractality than con-
(1 citation) trols in the parietal and occipital regions, indicative of
less diverse singularities and reduced variability in the
signal. In addition, supervised machine-learning, based
Altered Brain Criticality in Schizophrenia: New on logistic regression, successfully discriminated the
Insights From Magnetoencephalography (2022) two groups using measures of self-similarity and mul-
tifractality as features. Our results provide new insights
Alamian, Golnoush; Lajnef, Tarek; Pascarella, Annalisa; into the baseline cognitive functioning of schizophre-
Lina, Jean-Marc; Knight, Laura; Walters, James; Singh, nia patients by identifying key alterations of criticality
Krish D; Jerbi, Karim properties in their resting-state brain data.

CoCo Lab, Department of Psychology, Université de Montréal, Keywords: complexity, criticality, machine-learning, mag-
Montréal, QC, Canada; Institute for Applied Mathematics netoencephalography, multifractal analysis, resting-state,
Mauro Picone, National Research Council, Roma, Italy; Centre scale-free dynamics
UNIQUE, Union Neurosciences et Intelligence Artificielle -
Québec, Montréal, QC, Canada; CUBRIC, School of Psycholo- Frontiers in neural circuits (2022), Vol. 16 (35418839) (4
gy, College of Biomedical and Life Sciences, Cardiff University, citations)
Cardiff, United Kingdom; Division of Psychological Medicine
and Clinical Neurosciences, MRC Centre for Neuropsychiatric
Genetics and Genomics, School of Medicine, College of Bio- Disrupted local beta band networks in
medical and Life Sciences, Cardiff University, Cardiff, United schizophrenia revealed through graph analysis: A
Kingdom; MEG Center, Université de Montréal, Montréal, QC, magnetoencephalography study (2022)
Canada
Tagawa, Minami; Takei, Yuichi; Kato, Yutaka; Suto,
ABSTRACT Schizophrenia has a complex etiology and Tomohiro; Hironaga, Naruhito; Ohki, Takefumi;
symptomatology that is difficult to untangle. After Takahashi, Yumiko; Fujihara, Kazuyuki; Sakurai, Noriko;
decades of research, important advancements toward Ujita, Koichi; Tsushima, Yoshito; Fukuda, Masato
a central biomarker are still lacking. One of the miss-
ing pieces is a better understanding of how non-linear Gunma Prefectural Psychiatric Medical Center, Gunma,
neural dynamics are altered in this patient population. Japan; Department of Psychiatry and Neuroscience, Gunma
In this study, the resting-state neuromagnetic signals University Graduate School of Medicine, Gunma, Japan;
of schizophrenia patients and healthy controls were Tsutsuji Mental Hospital, Gunma, Japan; Brain Center, Faculty
analyzed in the framework of criticality. When biologi- of Medicine, Kyushu University, Fukuoka, Japan; International
cal systems like the brain are in a state of criticality, they Research Center for Neurointelligence (IRCN), The University
are thought to be functioning at maximum efficiency of Tokyo, Tokyo, Japan; Department of Genetic and Behavior-
(e.g., optimal communication and storage of informa- al Neuroscience, Gunma University Graduate School of Medi-
tion) and with maximum adaptability to incoming cine, Gunma, Japan; Department of Diagnostic Radiology
information. Here, we assessed the self-similarity and and Nuclear Medicine, Gunma University Graduate School of
multifractality of resting-state brain signals recorded Medicine, Gunma, Japan
with magnetoencephalography in patients with schizo-
phrenia patients and in matched controls. Schizophre- AIMS Schizophrenia (SZ) is characterized by psy-
nia patients had similar, although attenuated, patterns chotic symptoms and cognitive impairment, and is

 ontents  Index 263
C