Page 289 - MEGIN Book Of Abstracts - 2023

Govern Institute for Brain Research, Beijing Normal University, dom; Department of Child and Adolescent Psychiatry, Charité
Beijing 100875, China; BIH Visiting Professor, Stiftung Charité, Universitätsmedizin, Berlin, Germany; Institute of Neurosci-
Department of Psychiatry and Psychotherapy, Campus ence and Psychology, University of Glasgow, Glasgow, United
Charité Mitte, Charité - Universitätsmedizin, Berlin, Germany Kingdom; Neuroscience Centre, Helsinki Institute of Life Sci-
ence, University of Helsinki, Finland; Department of Neurosci-
ABSTRACT An ability to build structured mental maps ence and Biomedical Engineering, Aalto University, Finland
of the world underpins our capacity to imagine rela-
tionships between objects that extend beyond experi- ABSTRACT Long-Range Temporal Correlations (LRTCs)
ence. In rodents, such representations are supported by index the capacity of the brain to optimally process
sequential place cell reactivations during rest, known as information. Previous research has shown that patients
replay. Schizophrenia is proposed to reflect a compro- with chronic schizophrenia present altered LRTCs at
mise in structured mental representations, with animal alpha and beta oscillations. However, it is currently
models reporting abnormalities in hippocampal replay unclear at which stage of schizophrenia aberrant LRTCs
and associated ripple activity during rest. Here, utilizing emerge. To address this question, we investigated LRT-
magnetoencephalography (MEG), we tasked patients Cs in resting-state magnetoencephalographic (MEG)
with schizophrenia and control participants to infer un- recordings obtained from patients with affective disor-
observed relationships between objects by reorganiz- ders and substance abuse (clinically at low-risk of psy-
ing visual experiences containing these objects. During chosis, CHR-N), patients at clinical high-risk of psychosis
a post-task rest session, controls exhibited fast spon- (CHR-P) (n = 115), as well as patients with a first episode
taneous neural reactivation of presented objects that (FEP) (n = 25). Matched healthy controls (n = 47) served
replayed inferred relationships. Replay was coincident as comparison group. LRTCs were obtained for frequen-
with increased ripple power in hippocampus. Patients cies from 4 to 40 Hz and correlated with clinical and
showed both reduced replay and augmented ripple neuropsychological data. In addition, we examined the
power relative to controls, convergent with findings relationship between LRTCs and transition to psychosis
in animal models. These abnormalities are linked to in CHR-P participants, and the relationship between
impairments in behavioral acquisition and subsequent LRTC and antipsychotic medication in FEP participants.
neural representation of task structure. Our results show that participants from the clinical
groups have similar LRTCs to controls. In addition,
Keywords: cognitive map, mental simulation, model- LRTCs did not correlate with clinical and neurocogni-
based inference, psychosis, schema tive variables across participants nor did LRTCs predict
transition to psychosis. Therefore, impaired LRTCs do
Cell (2021), Vol. 184, No. 16 (34197734) (17 citations) not reflect a feature in the clinical trajectory of psy-
chosis. Nevertheless, reduced LRTCs in the beta-band
over posterior sensors of medicated FEP participants
Long range temporal correlations (LRTCs) in MEG- indicate that altered LRTCs may appear at the onset of
data during emerging psychosis: Relationship to the illness. Future studies are needed to elucidate the
symptoms, medication-status and clinical trajectory role of anti-psychotic medication in altered LRTCs.
(2021)
Keywords: Biomarker, Emerging-psychosis, Longrange-
Cruz, Gabriela; Grent-'t-Jong, Tineke; Krishnadas, temporal-correlations, Magnetoencephalography, Oscilla-
Rajeev; Palva, J Matias; Palva, Satu; Uhlhaas, Peter J tions, Schizophrenia

Institute of Neuroscience and Psychology, University of NeuroImage. Clinical (2021), Vol. 31 (34130193) (3
Glasgow, Glasgow, United Kingdom. Electronic address: citations)
gabriela.cruz@glasgow.ac.uk; Institute of Neuroscience and
Psychology, University of Glasgow, Glasgow, United King-

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