Page 293 - MEGIN Book Of Abstracts - 2023

olis, MN, United States; Department of Neurology, University University of California, Los Angeles, Franz Hall, 502 Portola
of California, San Francisco, San Francisco, CA, United States; Plaza, Los Angeles, CA 90095, USA; Department of Psychia-
Department of Radiology and Biomedical Imaging, Univer- try and Biobehavioral Sciences, University of California, Los
sity of California, San Francisco, San Francisco, CA, United Angeles, Los Angeles, CA 90095, USA
States; San Francisco Veterans' Affairs Medical Center, San
Francisco, CA, United States; Department of Neurology, Uni- ABSTRACT Schizophrenia (Sz) is a chronic mental dis-
versity of California, San Francisco, San Francisco, CA, United order characterized by disturbances in thought (such as
States. srikantan.nagarajan@ucsf.edu delusions and confused thinking), perception (hearing
voices), and behavior (lack of motivation). The lifetime
ABSTRACT Auditory working memory impairments prevalence of Sz is between 0.3% and 0.7%, with late
feature prominently in schizophrenia. However, the adolescence and early adulthood, the peak period for
existence of altered and perhaps compensatory neural the onset of psychotic symptoms. Causal factors in Sz
dynamics, sub-serving auditory working memory, include environmental and genetic factors and espe-
remains largely unexplored. We compared the dynam- cially their interaction. About 50% of individuals with a
ics of induced high gamma power (iHGP) across cortex diagnosis of Sz have lifelong impairment.
in humans during speech-sound working memory in
individuals with schizophrenia (SZ) and healthy com- Keywords: Magnetoencephalography, Neuroimaging,
parison subjects (HC) using magnetoencephalography Neuroradiologists, Schizophrenia
(MEG). SZ showed similar task performance to HC while
utilizing different brain regions. During encoding of Neuroimaging clinics of North America (2020), Vol. 30, No.
speech sounds, SZ lacked the correlation of iHGP with 2 (32336407) (3 citations)
task performance in posterior superior temporal gyrus
(STGp) that was observed in healthy subjects. Instead,
SZ recruited the visual word form area (VWFA) during Impaired theta phase coupling underlies
both stimulus encoding and response preparation. frontotemporal dysconnectivity in schizophrenia
Importantly, VWFA activity during encoding correlated (2020)
with the magnitude of SZ hallucinations, task perfor-
mance and an independent measure of verbal working Adams, Rick A; Bush, Daniel; Zheng, Fanfan; Meyer,
memory. These findings suggest that VWFA plasticity Sofie S; Kaplan, Raphael; Orfanos, Stelios; Marques,
is harnessed to compensate for STGp dysfunction in Tiago Reis; Howes, Oliver D; Burgess, Neil
schizophrenia patients with hallucinations.
Wellcome Centre for Human Neuroimaging, University
Scientific reports (2020), Vol. 10, No. 1 (32483253) (3 College London, 12 Queen Square, London, WC1N 3BG, UK;
citations) Queen Square Institute of Neurology, University College Lon-
don, London, WC1N 3BG, UK; Brainnetome Center, Institute
of Automation, Chinese Academy of Sciences, 95 Zhong-
Magnetoencephalography for Schizophrenia (2020) guancun East Road, 100190 Beijing, China; Kavli Institute for
Systems Neuroscience, Norwegian University of Science and
Edgar, J Christopher; Guha, Anika; Miller, Gregory A Technology, Trondheim, Norway; Department of Forensic
and Neurodevelopmental Sciences, Institute of Psychiatry,
Department of Radiology, Research Division, Children's Hos- Psychology, and Neuroscience, King's College London, De
pital of Philadelphia, 3401 Civic Center Boulevard, 1st Floor, Crespigny Park, Denmark Hill, London SE5 8AF, UK; Depart-
Room 115A, Philadelphia, PA 19104, USA. Electronic address: ment of Psychosis Studies, Institute of Psychiatry, Psychology
edgarj@email.chop.edu; Department of Psychology, Univer- and Neuroscience (IoPPN), King's College London, London,
sity of California, Los Angeles, Franz Hall, 502 Portola Plaza, SE5 8AF, UK
Los Angeles, CA 90095, USA; Department of Psychology,

 ontents  Index 272
C