Page 296 - MEGIN Book Of Abstracts - 2023

schizophrenia. The aims of this review are (a) to provide ing, we applied an anatomically constrained linear
an overview of recent findings in language processing estimation inverse model known as dynamic statistical
in schizophrenia with EEG and MEG using neurophysi- parametric mapping (MNE dSPM) and source-based
ological indices, providing insights into underlying connectivity using the weighted phase lag index.
language related pathophysiological deficits in this
disease and (b) to emphasize the advantage of EEG and RESULTS Across one week there was excellent test-re-
MEG in research on language processing in schizophre- test reliability in global spectral measures in theta-gam-
nia. ma bands (HC ICCAvg = 0.87, SZ ICCAvg = 0.87), region-
al spectral measures in all bands (HC ICCAvg = 0.86,
Keywords: electroencephalography (EEG), language SZ ICCAvg = 0.80), and parietal alpha measures (HC
processing, magnetoencephalography (MEG), neural ICCAvg = 0.90, SZ ICCAvg = 0.84). Conversely, functional
oscillation, schizophrenia connectivity had poor reliability, as did source spectral
power across one hour for SZ. Relative to HC, SZ also
Clinical EEG and neuroscience (2020), Vol. 51, No. 4 had reduced parietal alpha normalized power dur-
(31741393) (11 citations) ing eyes closed only, reduced alpha reactivity, and an
association between higher PANSS positive scores and
lower parietal alpha power.
Reduced parietal alpha power and psychotic
symptoms: Test-retest reliability of resting-state CONCLUSIONS There was excellent to good test-retest
magnetoencephalography in schizophrenia and reliability in most MEG spectral measures with a few
healthy controls (2020) exceptions in the schizophrenia patient group. Overall,
these findings encourage the use of resting-state MEG
Candelaria-Cook, Felicha T; Schendel, Megan E; Ojeda, while emphasizing the importance of determining reli-
Cesar J; Bustillo, Juan R; Stephen, Julia M ability in clinical populations.

The Mind Research Network, Albuquerque, NM, USA. Elec- Keywords: MEG, Resting-state, Schizophrenia, Spectral
tronic address: fccook@mrn.org; Department of Psychiatry power, Symptoms, Test-retest reliability
and Behavioral Sciences, Center for Psychiatric Research,
University of New Mexico School of Medicine, Albuquerque, Schizophrenia research (2020), Vol. 215 (31706785) (10
NM, USA citations)

BACKGROUND Despite increased reporting of resting-
state magnetoencephalography (MEG), reliability of Intervention-specific patterns of cortical function
those measures remains scarce and predominately plasticity during auditory encoding in people with
reported in healthy controls (HC). As such, there is schizophrenia (2020)
limited knowledge on MEG resting-state reliability in
schizophrenia (SZ). Dale, Corby L; Brown, Ethan G; Herman, Alexander B;
Hinkley, Leighton B N; Subramaniam, Karuna; Fisher,
METHODS To address test-retest reliability in psychosis, Melissa; Vinogradov, Sophia; Nagarajan, Srikantan S
a reproducibility study of 26 participants (13-SZ, 13-
HC) was performed. We collected eyes open and eyes Department of Radiology and Biomedical Imaging, Univer-
closed resting-state data during 4 separate instances sity of California San Francisco, United States; San Francisco
(2 Visits, 2 runs per visit) to estimate spectral power Veterans' Affairs Medical Center, United States. Electronic
reliability (power, normalized power, alpha reactivity) address: corby.dale@ucsf.edu; Weill Cornell Medical College,
across one hour and one week. Intraclass correlation New York, United States; Department of Radiology and
coefficients (ICCs) were calculated. For source model- Biomedical Imaging, University of California San Francisco,

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