Page 288 - MEGIN Book Of Abstracts - 2023

and glutamatergic neurotransmission in oscillatory performance relative to HC. Performance and FPAN
deficits in schizophrenia. Finally, we will highlight activity were not correlated in HC. Among FE, however,
methodological and analytical challenges as well as stronger activity within right hemisphere FEF and IFG
provide recommendations for future research. was associated with faster responses. Stronger right IPS
and left IFG activity in patients was also associated with
Keywords: EEG, MEG, neural oscillation, schizophrenia reduced negative symptoms and improved community
functioning, respectively. Increased reliance on the
Psychiatry and clinical neurosciences (2021), Vol. 75, No. FPAN for task completion suggests an inefficient cogni-
12 (34558155) (15 citations) tive control network and might reflect a compensation
for impaired attentional deployment during target de-
tection, a strategy employed by those with less severe
Fronto-parietal network function during cued visual illness. These findings represent a critical step towards
search in the first-episode schizophrenia spectrum identifying the neural substrates of negative symptoms
(2021) and impaired neurocognition at disease onset.

Sklar, Alfredo L; Coffman, Brian A; Salisbury, Dean F Keywords: Attention, First-episode, Fronto-parietal atten-
tion network, Magnetoencephalography, Schizophrenia
Clinical Neurophysiology Research Laboratory, Western
Psychiatric Hospital, Department of Psychiatry, University of Journal of psychiatric research (2021), Vol. 141 (34304038)
Pittsburgh School of Medicine, Pittsburgh, PA, USA; Western (3 citations)
Psychiatric Hospital, Department of Psychiatry, University of
Pittsburgh School of Medicine, Pittsburgh, PA, USA; Clinical
Neurophysiology Research Laboratory, Western Psychiatric Impaired neural replay of inferred relationships in
Hospital, Department of Psychiatry, University of Pittsburgh schizophrenia (2021)
School of Medicine, Pittsburgh, PA, USA; Western Psychiatric
Hospital, Department of Psychiatry, University of Pittsburgh Nour, Matthew M; Liu, Yunzhe; Arumuham, Atheeshaan;
School of Medicine, Pittsburgh, PA, USA. Electronic address: Kurth-Nelson, Zeb; Dolan, Raymond J
salisburyd@upmc.edu
Max Planck University College London Centre for Computa-
ABSTRACT Cognitive impairments account for sig- tional Psychiatry and Ageing Research, London WC1B 5EH,
nificant morbidity in schizophrenia and are present UK; Wellcome Centre for Human Neuroimaging (WCHN),
at disease onset. Controlled processes are particularly University College London, London WC1N 3AR, UK; Depart-
susceptible and may contribute to pervasive selective ment of Psychosis Studies, Institute of Psychiatry Psychology
attention deficits. The present study assessed fronto- and Neuroscience, King's College London, London SE5 8AF,
parietal attention network (FPAN) functioning during UK. Electronic address: matthew.nour.18@ucl.ac.uk; State Key
cue presentation on a visual search task in first-episode Laboratory of Cognitive Neuroscience and Learning, IDG/Mc-
schizophrenia spectrum patients (FE) and its relation Govern Institute for Brain Research, Beijing Normal University,
to symptom burden and community functioning. Brain Beijing 100875, China; Chinese Institute for Brain Research,
activity was recorded with magnetoencephalography Beijing 102206, China; Max Planck University College London
from 38 FE and 38 healthy controls (HC) during blocks Centre for Computational Psychiatry and Ageing Research,
of pop-out and serial search target detection. Activ- London WC1B 5EH, UK; Deepmind, London NC1 4AG, UK;
ity during cue presentation was compared between Max Planck University College London Centre for Computa-
groups across bilateral FPAN regions (frontal eye fields tional Psychiatry and Ageing Research, London WC1B 5EH,
(FEF), inferior frontal gyrus (IFG), midcingulate cortex UK; Wellcome Centre for Human Neuroimaging (WCHN),
(MCC), and intraparietal sulcus (IPS)). FE exhibited University College London, London WC1N 3AR, UK; State Key
greater right hemisphere IFG activity despite worse Laboratory of Cognitive Neuroscience and Learning, IDG/Mc-

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