Page 290 - MEGIN Book Of Abstracts - 2023

Patient, interrupted: MEG oscillation dynamics ized by reduced signal memory and higher variability
reveal temporal dysconnectivity in schizophrenia across time, as evidenced by cortical and subcortical
(2020) attenuations of LRTCs in the alpha and beta frequency
bands. Support vector machine significantly classified
Alamian, Golnoush; Pascarella, Annalisa; Lajnef, Tarek; participants using LRTCs in key limbic and paralimbic
Knight, Laura; Walters, James; Singh, Krish D; Jerbi, brain areas, with decoding accuracy reaching 82%. Im-
Karim portantly, these brain regions belong to networks that
are highly relevant to the symptomology of schizophre-
CoCo Lab, Department of Psychology, Université de Montréal, nia. These findings thus posit temporal dysconnectiv-
Canada. Electronic address: golnoush.alamian@umontreal. ity as a hallmark of altered information processing in
ca; Italian National Research Council, Rome, Italy; CUBRIC, schizophrenia, and help advance our understanding of
School of Psychology, College of Biomedical and Life Sci- this pathology.
ences, Cardiff University, UK; MRC Centre for Neuropsychiatric
Genetics and Genomics, Division of Psychological Medicine Keywords: Long-range-temporal-correlations, Machine-
and Clinical Neurosciences, School of Medicine, College of learning, Magnetoencephalography, Oscillations, Resting-
Biomedical and Life Sciences, Cardiff University, UK; CoCo Lab, state, Schizophrenia
Department of Psychology, Université de Montréal, Canada;
MEG Center, University of Montreal, Canada; UNIQUE Centre NeuroImage. Clinical (2020), Vol. 28 (33395976) (4
(Unifying AI and Neuroscience - Québec), Quebec, Canada; citations)
Mila (Quebec AI Institute), Montreal, QC, Canada; Centre
de recherche de l'Institut universitaire en santé mentale de
Montréal, Montreal, QC, Canada Motor-related oscillatory activity in schizophrenia
according to phase of illness and clinical symptom
ABSTRACT Current theories of schizophrenia em- severity (2021)
phasize the role of altered information integration
as the core dysfunction of this illness. While ample Gascoyne, Lauren E; Brookes, Matthew J; Rathnaiah,
neuroimaging evidence for such accounts comes from Mohanbabu; Katshu, Mohammad Zia Ul Haq; Koelewijn,
investigations of spatial connectivity, understanding Loes; Williams, Gemma; Kumar, Jyothika; Walters, James
temporal disruptions is important to fully capture the T R; Seedat, Zelekha A; Palaniyappan, Lena; Deakin, J F
essence of dysconnectivity in schizophrenia. Recent William; Singh, Krish D; Liddle, Peter F; Morris, Peter G
electrophysiology studies suggest that long-range
temporal correlation (LRTC) in the amplitude dynamics Sir Peter Mansfield Imaging Centre, School of Physics and As-
of neural oscillations captures the integrity of trans- tronomy, University of Nottingham, University Park, Notting-
ferred information in the healthy brain. Thus, in this ham NG7 2RD, United Kingdom. Electronic address: lauren.
study, 25 schizophrenia patients and 25 controls (8 [email protected]; Institute of Mental Health,
females/group) were recorded during two five-minutes University of Nottingham, Jubilee Campus, Nottingham NG7
of resting-state magnetoencephalography (once with 2TU, United Kingdom; Nottinghamshire Healthcare NHS
eyes-open and once with eyes-closed). We used source- Foundation Trust, Nottingham NG3 6AA, United Kingdom;
level analyses to investigate temporal dysconnectiv- CUBRIC, School of Psychology, College of Biomedical and Life
ity in patients by characterizing LRTCs across cortical Sciences, Cardiff, Cardiff University CF24 4HQ, United King-
and sub-cortical brain regions. In addition to standard dom; MRC Centre for Neuropsychiatric Genetics and Genom-
statistical assessments, we applied a machine learning ics, Cardiff University, CF24 4HQ, United Kingdom; Depart-
framework using support vector machine to evalu- ment of Psychiatry & Robarts Research Institute, University of
ate the discriminative power of LRTCs in identifying Western Ontario & Lawson Health Research Institute, London
patients from healthy controls. We found that neural ON, Canada; Division of Neuroscience and Experimental
oscillations in schizophrenia patients were character- Psychology, University of Manchester, Oxford Rd, Manchester

 ontents  Index 269
C