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source imaging. Participants included 25 symptomatic cussions for cognition particularly in mTBI. This is the
individuals with chronic combat-related blast mTBI and first human study to demonstrate abnormal resting-
35 healthy controls with similar combat experiences. state gamma activity in mTBI. These novel findings
Compared with controls, gamma activity was markedly suggest the possibility that abnormal gamma activities
elevated in mTBI participants throughout frontal, pari- may be a proxy for GABA-ergic interneuron dysfunction
etal, temporal, and occipital cortices, whereas gamma and a promising neuroimaging marker of insidious mild
activity was reduced in ventromedial prefrontal cortex. head injuries.
Across groups, greater gamma activity correlated with
poorer performances on tests of executive function- Keywords: cognition, frontoparietal network, gamma
ing and visuospatial processing. Many neurocogni- activity, magnetoencephalography, mild traumatic brain
tive associations, however, were partly driven by the injury
higher incidence of mTBI participants with both higher
gamma activity and poorer cognition, suggesting that Cerebral cortex (New York, N.Y.: 1991) (2020), Vol. 30, No. 1
expansive upregulation of gamma has negative reper- (31041986) (10 citations)

 ontents  Index 298
C