Page 317 - MEGIN Book Of Abstracts - 2023

studied. In mTBI, we found reductions in frontal beta Keywords: Functional connectivity, GABA-ergic, Gamma
and large-scale beta networks, indicative of thalamo- wave, Posttraumatic stress disorder, Slow wave, Traumatic
cortical dysconnectivity and disrupted information brain injury
flow through cortico-basal ganglia-thalamic circuits.
Relatively, connectivity more accurately classifies indi- Neuroimaging clinics of North America (2020), Vol. 30, No.
vidual mTBI cases compared with regional power. We 2 (32336405) (4 citations)
show the relevance of beta oscillations in mTBI and the
reliability of these markers in classification.
Resting-State Magnetoencephalography Source
Keywords: beta oscillations, concussion, machine learn- Imaging Pilot Study in Children with Mild Traumatic
ing, magnetoencephalography, neural activity Brain Injury (2020)

Journal of neurophysiology (2020), Vol. 124, No. 6 Huang, Ming-Xiong; Robb Swan, Ashley; Angeles
(33052746) (10 citations) Quinto, Annemarie; Huang, Jeffrey W; De-la-Garza,
Bianca G; Huang, Charles W; Hesselink, John R; Bigler,
Erin D; Wilde, Elisabeth A; Max, Jeffrey E
Magnetoencephalography for Mild Traumatic Brain
Injury and Posttraumatic Stress Disorder (2020) Radiology, Research, and Psychiatry Services, VA San Diego
Healthcare System, San Diego, California; Department of
Huang, Mingxiong; Lewine, Jeffrey David; Lee, Roland R Computer Sciences, Columbia University, New York, New
York; Department of Psychiatry, University of California, San
Department of Radiology, University of California, San Diego Diego, California; Department of Bioengineering, Stanford
and VA San Diego, UCSD Radiology Imaging Lab, 3510 University, Stanford, California; Department of Radiology,
Dunhill Street, San Diego, CA 92121, USA; The Mind Research University of California, San Diego, California; Department of
Network, 1101 Yale Boulevard, Albuquerque, NM 87106, Neurology, University of Utah, Salt Lake City, Utah; Depart-
USA; Department of Radiology, University of California, San ment of Psychiatry, Rady Children's Hospital, San Diego,
Diego and VA San Diego, UCSD Radiology Imaging Lab, 3510 California
Dunhill Street, San Diego, CA 92121, USA. Electronic address:
RRLEE@UCSD.EDU ABSTRACT Mild traumatic brain injury (mTBI) accounts
for the vast majority of all pediatric TBI. An important
ABSTRACT Mild traumatic brain injury (mTBI) and post- minority of children who have suffered an mTBI have
traumatic stress disorder (PTSD) are leading causes of enduring cognitive and emotional symptoms. How-
sustained physical, cognitive, emotional, and behav- ever, the mechanisms of chronic symptoms in children
ioral deficits in the general population, active-duty with pediatric mTBI are not fully understood. This is
military personnel, and veterans. However, the under- in part due to the limited sensitivity of conventional
lying pathophysiology of mTBI/PTSD and the mecha- neuroimaging technologies. The present study exam-
nisms that support functional recovery for some, but ined resting-state magnetoencephalography (rs-MEG)
not all individuals is not fully understood. Conventional source images in 12 children who had mTBI and 12
MR imaging and computed tomography are generally age-matched control children. The rs-MEG exams were
negative in mTBI and PTSD, so there is interest in the performed in children with mTBI 6 months after injury
development of alternative evaluative strategies. Of when they reported no clinically significant post-injury
particular note are magnetoencephalography (MEG) psychiatric changes and few if any somatic sensorimo-
-based methods, with mounting evidence that MEG tor symptoms but did report cognitive symptoms. MEG
can provide sensitive biomarkers for abnormalities in source magnitude images were obtained for different
mTBI and PTSD. frequency bands in alpha (8-12 Hz), beta (15-30 Hz),
gamma (30-90 Hz), and low-frequency (1-7 Hz) bands.

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