Page 313 - MEGIN Book Of Abstracts - 2023

in a multi-group context. The features from alpha and review examined the evidence for magnetoencepha-
beta bands exhibited the best classification perfor- lography (MEG) to provide an imaging biomarker in
mance, even in cases where distinction by concussion mild traumatic brain injury (mTBI).
symptom profiles alone were extremely difficult. We
demonstrate the potential of using 'invisible' neural METHODS Our review was prospectively registered on
indices of brain functioning to understand and differ- PROSPERO: CRD42019151387. We searched EMBASE,
entiate these debilitating conditions. MEDLINE, trial registers, PsycINFO, Cochrane Library
and conference abstracts and identified 37 papers
Translational psychiatry (2021), Vol. 11, No. 1 (34088901) (2 describing MEG changes in mTBI eligible for inclusion.
citations) Since meta-analysis was not possible, based on the
heterogeneity of reported outcomes, we provide a nar-
rative synthesis of results.
Magnetoencephalography abnormalities in adult
mild traumatic brain injury: A systematic review RESULTS The two most promising MEG biomarkers are
(2021) excess resting state low frequency power, and wide-
spread connectivity changes in all frequency bands.
Allen, Christopher M; Halsey, Lloyd; Topcu, Gogem; Rier, These may represent biomarkers with potential for
Lukas; Gascoyne, Lauren E; Scadding, John W; Furlong, diagnostic application, which reflect time sensitive
Paul L; Dunkley, Benjamin T; das Nair, Roshan; Brookes, changes, or may be capable of offering clinically rel-
Matthew J; Evangelou, Nikos evant prognostic information. In addition, the rich data
that MEG produces are well-suited to new methods of
Mental Health and Clinical Neurosciences Academic Unit, machine learning analysis, which is now being actively
School of Medicine, University of Nottingham, Queen's Medi- explored.
cal Centre, Nottingham NG7 2UH, United Kingdom. Elec-
tronic address: christopher.allen@nottingham.ac.uk; Mental INTERPRETATION MEG reveals several promising
Health and Clinical Neurosciences Academic Unit, School biomarkers, in the absence of structural abnormalities
of Medicine, University of Nottingham, Jubilee Campus, demonstrable with either computerised tomography
Nottingham NG8 1BB, United Kingdom; Sir Peter Mansfield or magnetic resonance imaging. This review has not
Imaging Centre, School of Physics & Astronomy, University of identified sufficient evidence to support routine clinical
Nottingham, University Park, Nottingham NG7 2RD, United use of MEG in mTBI currently. However, verifying MEG's
Kingdom; National Hospital for Neurology and Neurosurgery, potential would help meet an urgent clinical need
Queen Square, London WC1N 3BG, United Kingdom; College within civilian, sports and military medicine.
of Health and Life Sciences, Institute of Health and Neurode-
velopment, Aston University, The Aston Triangle, Birmingham Keywords: Magnetoencephalography, Mild traumatic
B4 7ET, United Kingdom; Department of Medical Imaging, brain injury, Systematic review
University of Toronto. 263 McCaul Street, Toronto M5T 1W7,
Canada NeuroImage. Clinical (2021), Vol. 31 (34010785) (7
citations)
BACKGROUND The global incidence of traumatic brain
injuries is rising, with at least 80% being classified as
mild. These mild injuries are not visible on routine Magnetoencephalography in the Detection and
clinical imaging. The potential clinical role of a specific Characterization of Brain Abnormalities Associated
imaging biomarker be it diagnostic, prognostic or di- with Traumatic Brain Injury: A Comprehensive
recting and monitoring progress of personalised treat- Review (2021)
ment and rehabilitation has driven the exploration of
several new neuroimaging modalities. This systematic Peitz, Geoffrey W; Wilde, Elisabeth A; Grandhi, Ramesh

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