Page 311 - MEGIN Book Of Abstracts - 2023

CONCLUSIONS This is the first systemic review of controls at 2 time points (preseason, postseason). Time-
neuroimaging changes associated with anxiety after series from the default mode network regions were
TBI, which implicated multiple brain structures and extracted, and effective connectivity between them
circuits, such as the default mode network. Future was computed for 5 different frequency bands. The de-
research with consistent, rigorous measurements of TBI fault mode network regions were grouped into anterior
and syndromal anxiety, as well as attention to control and posterior default mode networks. The combined
groups, previous TBIs, and time interval between TBI posterior-to-anterior and anterior-to-posterior effective
and neuroimaging, are warranted. By understanding connectivity values were averaged to generate 2 sets of
neuroimaging correlates of psychiatric symptoms, this values for each subject. The effective connectivity val-
work could inform future post-TBI screening and sur- ues were compared using a repeated measures ANOVA
veillance, preventative efforts, and early interventions across time points for the concussed, nonconcussed,
to improve neuropsychiatric outcomes. and control groups, separately.

Keywords: anxiety, neuroimaging, neuropsychiatric symp- RESULTS A significant increase in posterior-to-anterior
toms, traumatic brain injury effective connectivity from preseason to postconcus-
sion (corrected P value = .013) and a significant de-
Journal of the Academy of Consultation-Liaison Psychiatry crease in posterior-to-anterior effective connectivity
(2022), Vol. 63, No. 2 (34534701) (1 citation) from postconcussion to postseason (corrected P value
= .028) were observed in the concussed group. Chang-
es in effective connectivity were only significant within
Alterations in the Magnetoencephalography the delta band. Anterior-to-posterior connectivity dem-
Default Mode Effective Connectivity following onstrated no significant change. Effective connectivity
Concussion (2021) in the nonconcussed group and controls did not show
significant differences.
Reddy, D D; Davenport, E M; Yu, F F; Wagner, B; Urban, J
E; Whitlow, C T; Stitzel, J D; Maldjian, J A CONCLUSIONS The unidirectional increase in effective
connectivity postconcussion may elucidate compensa-
From the Department of Radiology (D.D.R., E.M.D., F.F.Y., B.W., tory processes, invoking use of posterior regions to aid
J.A.M.), University of Texas Southwestern, Dallas, Texas divya. the function of susceptible anterior regions following
reddy@utsouthwestern.edu; Wake Forest School of Medicine brain injury. These findings support the potential value
(J.E.U. C.T.W., J.D.S.), Winston-Salem, North Carolina of magnetoencephalography in exploring directional
changes of the brain network following concussion.
BACKGROUND AND PURPOSE Magnetoencephalog-
raphy is sensitive to functional connectivity changes AJNR. American journal of neuroradiology (2021), Vol. 42,
associated with concussion. However, the directional No. 10 (34503943) (1 citation)
influences between functionally related regions remain
unexplored. In this study, we therefore evaluated
concussion-related magnetoencephalography-based Alterations in the Topology of Functional
effective connectivity changes within resting-state Connectomes Are Associated with Post-Traumatic
default mode network regions. Stress Disorder and Blast-Related Mild Traumatic
Brain Injury in Combat Veterans (2021)
MATERIALS AND METHODS Resting-state magnetoen-
cephalography was acquired for 8 high school football Rowland, Jared A; Stapleton-Kotloski, Jennifer R;
players with concussion at 3 time points (preseason, Martindale, Sarah L; Rogers, Emily E; Ord, Anna S;
postconcussion, postseason), as well as 8 high school Godwin, Dwayne W; Taber, Katherine H
football players without concussion and 8 age-matched

 ontents  Index 290
C