Page 306 - MEGIN Book Of Abstracts - 2023

Keywords: Magnetoencephalography, Plasticity, Subacute β-Oscillations Reflect Recovery of the Paretic Upper
stroke, Transcallosal inhibition, Transcranial direct current Limb in Subacute Stroke (2020)
stimulation, Transcranial magnetic stimulation
Tang, Chih-Wei; Hsiao, Fu-Jung; Lee, Po-Lei; Tsai, Yun-
Journal of neuroengineering and rehabilitation (2020), Vol. An; Hsu, Ya-Fang; Chen, Wei-Ta; Lin, Yung-Yang; Stagg,
17, No. 1 (32527268) (9 citations) Charlotte J; Lee, I-Hui

Far Eastern Memorial Hospital, New Taipei City, Taiwan; Insti-
The sensitivity of event-related potentials/fields tute of Brain Science, National Yang-Ming University, Taipei,
to logopedic interventions in patients with stroke- Taiwan; National Central University, Taoyuan County, Taiwan;
related aphasia (2020) Taipei Veterans General Hospital, Taipei, Taiwan; Chiali Chi-
Mei Hospital, Tainan, Taiwan; National Yang-Ming University
Cocquyt, Elissa-Marie; Vandewiele, Marie; Bonnarens, School of Medicine, Taipei, Taiwan; University of Oxford, UK
Cindy; Santens, Patrick; De Letter, Miet
ABSTRACT Background. Recovery of upper limb
Department of Rehabilitation Sciences, Ghent University, function post-stroke can be partly predicted by initial
Corneel Heymanslaan 10, 2P1, 9000, Ghent, Belgium. Elissa- motor function, but the mechanisms underpinning
Marie.Cocquyt@UGent.be; Department of Neurology, Ghent these improvements have yet to be determined. Here,
University Hospital, Corneel Heymanslaan 10, 13K12, 9000, we sought to identify neural correlates of post-stroke
Ghent, Belgium recovery using longitudinal magnetoencephalography
(MEG) assessments in subacute stroke survivors. Meth-
ABSTRACT Recovery of stroke-related aphasia can ods. First-ever, subcortical ischemic stroke survivors
be affected by language therapy in the early and with unilateral mild to moderate hand paresis were
chronic stage. Objectively monitoring therapy-induced evaluated at 3, 5, and 12 weeks after stroke using a
neuroplasticity is possible by several measurement finger-lifting task in the MEG. Cortical activity patterns
techniques including electro- and magneto-encepha- in the β-band (16-30 Hz) were compared with matched
lography. The obtained event-related potentials (ERPs) healthy controls. Results. All stroke survivors (n=22; 17
and fields (ERFs) provide insights into the neural basis males) had improvements in action research arm test
of intact or deficient language processing with millisec- (ARAT) and Fugl-Meyer upper extremity (FM-UE) scores
onds precision. In this literature review, we highlight between 3 and 12 weeks. At 3 weeks post-stroke the
the sensitivity of ERPs and ERFs to logopedic interven- peak amplitudes of the movement-related ipsilesional
tions by providing an overview of therapy-induced β-band event-related desynchronization (β-ERD) and
changes in the amplitude, latency and topography of synchronization (β-ERS) in primary motor cortex (M1)
early and mid-to-late components. were significantly lower than the healthy controls
(p<0.001) and were correlated with both the FM-UE
Keywords: Aphasia, Event-related fields, Event-related and ARAT scores (r=0.51-0.69, p<0.017). The decreased
potentials, Language therapy, Neuroplasticity, Stroke β-ERS peak amplitudes were observed both in paretic
and non-paretic hand movement particularly at 3
Acta neurologica Belgica (2020), Vol. 120, No. 4 (32474880) weeks post-stroke, suggesting a generalized disinhibi-
(5 citations) tion status. The peak amplitudes of ipsilesional β-ERS
at week 3 post-stroke correlated with the FM-UE score
at 12 weeks (r=0.54, p=0.03) but no longer significant
when controlling for the FM-UE score at 3 weeks post-
stroke.Conclusions. Although early β-band activity does
not independently predict outcome at 3 months after
stroke, it mirrors functional changes, giving a potential

 ontents  Index 285
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