Page 307 - MEGIN Book Of Abstracts - 2023

insight into the mechanisms underpinning recovery of METHODS The AERs in 29 stroke survivors and 14
motor function in subacute stroke. controls were recorded with single tones, active and
passive frequency-oddballs, and a dual-oddball with
Keywords: event-related desynchronization, event-related pitch-contour and time-interval deviants. Performance
synchronization, magnetoencephalography, motor recov- in speech-in-noise, mistuning detection, and moving-
ery, stroke, β-oscillations sound detection was assessed. Relationships between
AERs, behaviour, and lesion overlap with functional
Neurorehabilitation and neural repair (2020), Vol. 34, No. 5 networks, were examined.
(32321366) (12 citations)
RESULTS Despite their normal hearing, eight patients
showed unilateral AER in the hemisphere ipsilateral to
Central auditory processing in adults with the affected hand with reduced amplitude compared
chronic stroke without hearing loss: A to those with bilateral AERs. Both groups showed in-
magnetoencephalography study (2020) creasing attenuation of later components. Hemispheric
asymmetry of AER sources was reduced in bilateral-AER
Fujioka, Takako; Freigang, Claudia; Honjo, Kie; Chen, J patients. The N1 wave (100 ms latency) and P2 (200 ms)
Jean; Chen, Joyce L; Black, Sandra E; Stuss, Donald T; were delayed in individuals with lesions in the basal-
Dawson, Deirdre R; Ross, Bernhard ganglia and white-matter, while lesions in the attention
network reduced the frequency-MMN (mismatch nega-
Rotman Research Institute, Baycrest Centre, Toronto, ON, tivity) responses and increased the pitch-contour P3a
Canada; Department of Music, Stanford University, CA, USA; response. Patients' impaired speech-in-noise percep-
Wu Tsai Neurosciences Institute, Stanford University, CA, tion was explained by AER measures and frequency-de-
USA; Sunnybrook Research Institute, Toronto, ON, Canada; viant detection performance with multiple regression.
Heart and Stroke Foundation, Canadian Partnership for
Stroke Recovery, Toronto, ON, Canada; Rotman Research CONCLUSION AERs reflect disruption of auditory
Institute, Baycrest Centre, Toronto, ON, Canada; University of functions due to damage outside of temporal lobe,
Toronto, Toronto, ON, Canada; University of Toronto, Toronto, and further explain complexity of neural mechanisms
ON, Canada; Sunnybrook Research Institute, Toronto, ON, underlying higher-order auditory perception.
Canada; Heart and Stroke Foundation, Canadian Partnership
for Stroke Recovery, Toronto, ON, Canada; Rotman Research SIGNIFICANCE Stroke survivors without obvious
Institute, Baycrest Centre, Toronto, ON, Canada; University hearing problems may benefit from rehabilitation for
of Toronto, Toronto, ON, Canada. Electronic address: bross@ central auditory processing.
research.baycrest.org
Keywords: Auditory evoked responses, Central auditory
OBJECTIVE Stroke lesions in non-auditory areas may processing, Chronic stroke, Hearing, Magnetoencephalog-
affect higher-order central auditory processing. We raphy, Mismatch negativity
sought to characterize auditory functions in chronic
stroke survivors with unilateral arm/hand impairment Clinical neurophysiology: official journal of the
using auditory evoked responses (AERs) with lesion and International Federation of Clinical Neurophysiology
perception metrics. (2020), Vol. 131, No. 5 (32200092) (0 citations)

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