Page 310 - MEGIN Book Of Abstracts - 2023

this paper, we employ this model to investigate mTBI. Maryland Healthcare System, Baltimore, MD; Sheppard Pratt,
We applied a Hidden Markov Model to MEG data re- Baltimore, MD; University of Maryland School of Medicine,
corded during resting state and a motor task and show Baltimore, MD; Welch Medical Library, Johns Hopkins Univer-
that previous findings of diminished intrinsic beta am- sity, Baltimore, MD; Mesulam Center for Cognitive Neurology
plitude in individuals with mTBI are largely due to the and Alzheimer's Disease & Northwestern University Feinberg
reduced beta band spectral content of bursts, and that School of Medicine, Chicago, IL; Department of Psychiatry
diminished beta connectivity results from a loss in the and Behavioral Sciences, Johns Hopkins University School
temporal coincidence of burst states. In a motor task, of Medicine, Baltimore, MD. Electronic address: matthew.
mTBI results in diminished burst amplitude, altered peters@jh.edu
modulation of burst probability during movement, and
a loss in connectivity in motor networks. These results BACKGROUND Traumatic brain injury (TBI) can pre-
suggest that, mechanistically, mTBI disrupts the struc- cipitate new-onset psychiatric symptoms or worsen
tural framework underlying neural synchrony, which existing psychiatric conditions. To elucidate specific
impairs network function. Whilst the damage may mechanisms for this interaction, neuroimaging is often
be too subtle for structural imaging to see, the func- used to study both psychiatric conditions and TBI. This
tional consequences are detectable and persist after systematic review aims to synthesize the existing lit-
injury. Our work shows that mTBI impairs the dynamic erature of neuroimaging findings among patients with
coordination of neural network activity and proposes a anxiety after TBI.
potent new method for understanding mTBI.
METHODS We conducted a Preferred Reporting Items
Keywords: Beta bursts, Concussion, MEG, Networks, mTBI, for Systematic Review and Meta-Analyses-compliant
mild Traumatic Brain Injury literature search via PubMed (MEDLINE), PsychINFO,
EMBASE, and Scopus databases before May, 2019. We
NeuroImage. Clinical (2021), Vol. 32 (34653838) (1 citation) included studies that clearly defined TBI, measured
syndromal anxiety as a primary outcome, and statisti-
cally analyzed the relationship between neuroimaging
Neuroimaging Correlates of Syndromal Anxiety findings and anxiety symptoms.
Following Traumatic Brain Injury: A Systematic
Review of the Literature (2022) RESULTS A total of 5982 articles were retrieved from
the systematic search, of which 65 studied anxiety and
Jahed, Sahar; Daneshvari, Nicholas O; Liang, Angela 13 met eligibility criteria. These studies were published
L; Richey, Lisa N; Bryant, Barry R; Krieg, Akshay; Bray, between 2004 and 2017, collectively analyzing 764
Michael J C; Pradeep, Tejus; Luna, Licia P; Trapp, participants comprised of 470 patients with TBI and
Nicholas T; Jones, Melissa B; Stevens, Daniel A; Roper, 294 non-TBI controls. Imaging modalities used included
Carrie; Goldwaser, Eric L; Berich-Anastasio, Emily; magnetic resonance imaging, functional magnetic
Pletnikova, Alexandra; Lobner, Katie; Lee, Daniel J; resonance imaging, diffusion tensor imaging, electro-
Lauterbach, Margo; Sair, Haris I; Peters, Matthew E encephalogram, magnetic resonance spectrometry,
and magnetoencephalography. Eight of 13 studies
Department of Psychiatry and Behavioral Sciences, Johns presented at least one significant finding and together
Hopkins University School of Medicine, Baltimore, MD; reflect a complex set of changes that lead to anxiety in
Department of Radiology and Radiological Science, Johns the setting of TBI. The left cingulate gyrus in particular
Hopkins University School of Medicine, Baltimore, MD; was found to be significant in 2 studies using different
Department of Psychiatry, University of Iowa Carver Col- imaging modalities. Two studies also revealed pertur-
lege of Medicine, Iowa City, IA; Menninger Department of bances in functional connectivity within the default
Psychiatry and Behavioral Sciences, Michael E. DeBakey VA mode network.
Medical Center & Baylor College of Medicine, Houston, TX; VA

 ontents  Index 289
C