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istics for dynamical approaches to identify brain areas presentation with generalized epileptiform discharges
involved in seizure generation. We show the non- were rarely reported.
invasive ViEEG approach may have some advantage
over intracranial electroencephalography (iEEG). Future CONCLUSION The presence of MCD does not preclude
work may be designed to test the potential of the a patient from having other types of epilepsy. General-
virtual iEEG approach for use in surgical management ized epilepsy and focal related epilepsy have a distinct
of epilepsy. pathophysiology.

Nature communications (2022), Vol. 13, No. 1 (35194035) Keywords: EEG, Epilepsy, MEG, MRI, focal cortical dysplasia
(4 citations)
Medical archives (Sarajevo, Bosnia and Herzegovina)
(2021), Vol. 75, No. 6 (35169375) (0 citations)
Focal Cortical Dysplasia and Generalized
Epileptiform Discharges: Case Report and Literature
Review (2021) Assessment of Effective Network Connectivity
among MEG None Contaminated Epileptic
Algethami, Hanin; Poghosyan, Vahe; Baksh, Eman; Transitory Events (2021)
Alhameed, Majed
Hadriche, Abir; Behy, Ichrak; Necibi, Amal; Kachouri,
King Salman Hospital, Riyadh, Saudi Arabia; King Fahad Abdennaceur; Amar, Chokri Ben; Jmail, Nawel
Medical City, Riyadh, Saudi Arabia; Department of Radiology
and Medical Imaging, King Fahad Medical City, Riyadh, Saudi Digital Research Center of Sfax, Tunisia; MIRACL Lab, Sfax
Arabia; Neurology Department, Neuro-Science Center, King University, Tunisia; LETI Lab, ENIS, Sfax University, Tunisia;
Fahad Medical City, Riyadh, Saudi Arabia REGIM Lab, ENIS, Sfax University, Tunisia

BACKGROUND Focal epilepsy can have a varied etiol- ABSTRACT Characterizing epileptogenic zones EZ
ogy, including malformations of cortical development (sources responsible of excessive discharges) would
(MCD), that can often be detected by Magnetic Reso- assist a neurologist during epilepsy diagnosis. Locating
nance Imaging (MRI).Here we show a distinct charac- efficiently these abnormal sources among magnetoen-
teristic of two forms of MCDs on MRI, with two tight cephalography (MEG) biomarker is obtained by several
dipole clusters in her MEG magnetoencephalography inverse problem techniques. These techniques present
study, in a patient with electroencephalography (EEG) different assumptions and particular epileptic network
features of generalized epilepsy. connectivity. Here, we proposed to evaluate perfor-
mances of distributed inverse problem in defining EZ.
CASE REPORT This is a case presentation of a 20 First, we applied an advanced technique based on Sin-
years old female with epilepsy, found to have upon gular Value Decomposition (SVD) to recover only pure
EMU admission two pathologies (FCD, heterotropia) transitory activities (interictal epileptiform discharges).
over the right side near the collateral sulcus, and two We evaluated our technique's robustness in separation
tight clusters of dipoles over the right parietal and between transitory and ripples versus frequency range,
left temporo-parietal region, with generalized inter transitory shapes, and signal to noise ratio on simulated
ictal discharges in her EEG. FCD is a common etiology data (depicting both epileptic biomarkers and respect-
of medically intractable seizures and usually in EEG it ing time series and spectral properties of realistic
will show either: pseudo-periodic spikes or rhythmic data). We validated our technique on MEG signal using
spikes, poly-spike or repetitive electrographic seizures detector precision on 5 patients. Then, we applied four
or a brief discharge of fast rhythmic activity, atypical methods of inverse problem to define cortical areas
and neural generators of excessive discharges. We

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