Page 161 - MEGIN Book Of Abstracts - 2023

Nanjing, China. 380013@njucm.edu.cn [[18]F]FDG PET/MRI and magnetoencephalography
may improve presurgical localization of temporal
ABSTRACT To evaluate the relationship between the lobe epilepsy (2022)
network metrics of 68 brain regions and duration of
temporal lobe epilepsy (TLE). Magnetoencephalogra- Guo, Kun; Wang, Jingjuan; Cui, Bixiao; Wang, Yihe; Hou,
phy (MEG) data from 53 patients with TLE (28 left TLE, Yaqin; Zhao, Guoguang; Lu, Jie
25 right TLE) were recorded between seizures at resting
state and analyzed in six frequency bands: delta (0.1- Department of Radiology and Nuclear Medicine, Xuanwu
4 Hz), theta (4-8 Hz), lower alpha (8-10 Hz), upper alpha Hospital Capital Medical University, Beijing, 100053, China;
(10-13 Hz), beta (13-30 Hz), and lower gamma (30- Department of Neurosurgery, Xuanwu Hospital, Capital
48 Hz). Three local network metrics, betweenness cen- Medical University, Beijing, China; Key Laboratory of Magnet-
trality, nodal degree, and nodal efficiency, were chosen ic Resonance Imaging and Brain Informatics, Beijing, China.
to analyze the functional brain network. In Left, Right, imaginglu@hotmail.com
and All (Left + Right) TLE groups, different metrics pro-
vide significant positive or negative correlations with OBJECTIVES To evaluate the clinical value of the com-
the duration of TLE, in different frequency bands, and in bination of [[18]F]FDG PET/MRI and magnetoencepha-
different brain regions. In the Left TLE group, significant lography (MEG) ([[18]F]FDG PET/MRI/MEG) in localizing
correlation between TLE duration and metric exists in the epileptogenic zone (EZ) in temporal lobe epilepsy
the delta, beta, or lower gamma band, with network (TLE) patients.
betweenness centrality, nodal degree, or nodal efficien-
cy, in left caudal middle frontal, left middle temporal, METHODS Seventy-three patients with localization-re-
or left supramarginal. In the Right TLE group, significant lated TLE who underwent [[18]F]FDG PET/MRI and MEG
correlation exists in lower gamma or delta band, with were enrolled retrospectively. PET/MRI images were
nodal degree, or nodal efficiency, in left precuneus or interpreted by two radiologists; the focal hypometabo-
right temporal pole. In the All TLE group, the significant lism on PET was identified using statistical parametric
correlation exists in delta, theta, beta, or lower gamma mapping (SPM). MEG spike sources were co-registered
band, with nodal degree, or betweenness centrality, onto T1-weighted sequence and analyzed by Neuro-
in either left or right hemisphere. Network metrics mag software. The clinical value of [[18]F]FDG PET/MRI,
for some specific brain regions changed in patients MEG, and PET/MRI/MEG in locating the EZ was assessed
with TLE as the duration of their TLE increased. Fur- using cortical resection and surgical outcomes as cri-
ther researching these changes may be important for teria. The correlations between surgical outcomes and
studying the pathogenesis, presurgical evaluation, and modalities concordant or non-concordant with cortical
clinical treatment of long-term TLE. resection were analyzed.

Keywords: Brain network, Functional connectivity, Magne- RESULTS For 46.6% (34/73) of patients, MRI showed
toencephalography, Temporal lobe epilepsy definitely structural abnormality concordant with surgi-
cal resection. SPM results of [[18]F]FDG PET showed
Brain topography (2021), Vol. 34, No. 6 (34652579) (0 focal temporal lobe hypometabolism concordant
citations) with surgical resection in 67.1% (49/73) of patients,
while the concordant cases increased to 82.2% (60/73)
patients with simultaneous MRI co-registration. MEG
was concordant with surgical resection in 71.2% (52/73)
of patients. The lobar localization was defined in 94.5%
(69/73) of patients by the [[18]F]FDG PET/MRI/MEG.
The results of PET/MRI/MEG concordance with surgi-
cal resection were significantly higher than that of

 ontents  Index 140
C