Page 163 - MEGIN Book Of Abstracts - 2023

seizure outcomes, but both were highly correlated with electrophysiological data. Some of these biomark-
the protocol group (i.e., independent test effects could ers are able to delineate the EZ with high precision,
not be demonstrated). augment the presurgical evaluation, and predict the
surgical outcome of patients with DRE undergoing
CONCLUSIONS A new presurgical evaluation strategy surgery. However, the use of these epilepsy biomarkers
for children with PDCs of focal epilepsy led to improved in clinical practice is limited. Here, we summarize and
postsurgical seizure freedom. No individual presurgi- discuss the latest technological advances in the pre-
cal evaluation test was independently associated with surgical neurophysiological evaluation of children with
improved outcome, suggesting that it may be the com- DRE with emphasis on electric and magnetic source
bined systematic protocol and new interinstitutional imaging, high frequency oscillations, and functional
collaborations that makes the difference rather than connectivity.
any individual test.
Seminars in pediatric neurology (2021), Vol. 39 (34620466)
Keywords: children, focal epilepsy, neuroimaging, out- (3 citations)
comes, presurgical evaluation, protocol

Journal of neurosurgery. Pediatrics (2022), Vol. 29, No. 1 Presurgical Evaluation Strategies for Intractable
(34624842) (1 citation) Epilepsy of Childhood (2021)

Starnes, Keith; Depositario-Cabacar, Dewi; Wong-Kisiel,
Localizing the Epileptogenic Zone with Novel Lily
Biomarkers (2021)
Department of Neurology, Mayo Clinic, Rochester, MN; De-
Papadelis, Christos; Perry, M Scott partment of Neurology, Children's National Medical Center,
Washington DC; Department of Neurology and Pediatrics,
Jane and John Justin Neurosciences Center, Cook Children's Mayo Clinic, Rochester, MN. Electronic address: wongkisiel.
Health Care System, Fort Worth, TX; School of Medicine, Texas [email protected]
Christian University and University of North Texas Health
Science Center, Fort Worth, TX; Department of Bioengineer- ABSTRACT For children who continue to experience
ing, University of Texas at Arlington, Arlington, TX; Division seizures despite treatment with antiseizure medica-
of Newborn Medicine, Department of Medicine, Boston tions, epilepsy surgery can be considered. The goals
Children's Hospital, Harvard Medical School, Boston, MA. of the presurgical evaluation are to determine the
Electronic address: [email protected] best surgical approach to render a good outcome. In
patients with drug resistant focal epilepsy, the epilep-
ABSTRACT Several noninvasive methods, such as togenic zone defines the minimal brain volume which
high-density EEG or magnetoencephalography, are must be resected for surgical success and to delineate
currently used to delineate the epileptogenic zone (EZ) the relationship of this region with functional cortex.
during the presurgical evaluation of patients with drug A number of noninvasive tools for these tasks have
resistant epilepsy (DRE). Yet, none of these methods emerged over the past decade, and existing technolo-
can reliably identify the EZ by their own. In most gies have been revised and improved. In this review,
cases a multimodal approach is needed. Challenging we examine the recent published evidence for these
cases often require the implantation of intracranial techniques, specifically as applied to the pediatric
electrodes, either through stereo-taxic EEG or electro- population. Discussed herein are the diagnostic value
corticography. Recently, a growing body of literature of methods such as video electroencephalography,
introduces novel biomarkers of epilepsy that can be magnetic resonance imaging, and supportive neu-
used for analyzing both invasive as well as noninvasive roimaging techniques including single photon emis-

 ontents  Index 142
C