Page 164 - MEGIN Book Of Abstracts - 2023

sion tomography, photon emission tomography, and Heemstede 2103 SW, Heemstede, the Netherlands; Depart-
magnetoencephalography. Functional testing includ- ment of Integrative Neurophysiology, Center for Neuroge-
ing functional magnetic resonance imaging, electri- nomics and Cognitive Research (CNCR), Vrije Universiteit
cal stimulation mapping, and transcranial magnetic Amsterdam, Amsterdam Neuroscience, 1081 HV, Amsterdam,
stimulation are considered in the context of pediatric the Netherlands; Department of Human Biology, Division of
epilepsy. The application of emerging techniques to Cell Biology, Neuroscience Institute, University of Cape Town,
preoperative testing such as source localization, image 7935, Cape Town, South Africa
post-processing, and artificial intelligence is covered.
We summarize the relative value of presurgical testing ABSTRACT Temporal lobe epilepsy (TLE) patients are
based on patient characteristics, including lesional or at risk of memory deficits, which have been linked to
nonlesional MRI, temporal or extratemporal epilepsy, functional network disturbances, particularly of inte-
and other factors relevant in pediatric epilepsy such as gration of the default mode network (DMN). However,
pathological substrate and age. the cellular substrates of functional network integration
are unknown. We leverage a unique cross-scale dataset
Seminars in pediatric neurology (2021), Vol. 39 (34620457) of drug-resistant TLE patients (n = 31), who underwent
(2 citations) pseudo resting-state functional magnetic resonance
imaging (fMRI), resting-state magnetoencephalogra-
phy (MEG) and/or neuropsychological testing before
Cellular Substrates of Functional Network neurosurgery. fMRI and MEG underwent atlas-based
Integration and Memory in Temporal Lobe Epilepsy connectivity analyses. Functional network centrality
(2022) of the lateral middle temporal gyrus, part of the DMN,
was used as a measure of local network integration.
Douw, Linda; Nissen, Ida A; Fitzsimmons, Sophie M D D; Subsequently, non-pathological cortical tissue from
Santos, Fernando A N; Hillebrand, Arjan; van Straaten, this region was used for single cell morphological and
Elisabeth C W; Stam, Cornelis J; De Witt Hamer, Philip C; electrophysiological patch-clamp analysis, assessing
Baayen, Johannes C; Klein, Martin; Reijneveld, Jaap C; integration in terms of total dendritic length and action
Heyer, Djai B; Verhoog, Matthijs B; Wilbers, René; Hunt, potential rise speed. As could be hypothesized, greater
Sarah; Mansvelder, Huibert D; Geurts, Jeroen J G; de network centrality related to better memory perfor-
Kock, Christiaan P J; Goriounova, Natalia A mance. Moreover, greater network centrality correlated
with more integrative properties at the cellular level
Department of Radiology, Athinoula A. Martinos Center for across patients. We conclude that individual differences
Biomedical Imaging, Massachusetts General Hospital, 02129 in cognitively relevant functional network integration
MA, Charlestown, USA; Department of Clinical Neurophysiol- of a DMN region are mirrored by differences in cellular
ogy and MEG Center, Amsterdam UMC, Vrije Universiteit Am- integrative properties of this region in TLE patients.
sterdam, Amsterdam Neuroscience, 1081 HV, Amsterdam, the These findings connect previously separate scales of
Netherlands; Department of Anatomy and Neurosciences, investigation, increasing translational insight into focal
Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam pathology and large-scale network disturbances in TLE.
Neuroscience, 1081 HV, Amsterdam, the Netherlands; De-
partment of Neurosurgery, Amsterdam UMC, Vrije Univer- Keywords: action potential kinetics, cellular morphology,
siteit Amsterdam, Amsterdam Neuroscience, VUmc Cancer connectome, graph theory, resting-state fMRI
Center Amsterdam Brain Tumor Center Amsterdam, 1081
HV, Amsterdam, the Netherlands; Department of Medical Cerebral cortex (New York, N.Y.: 1991) (2022), Vol. 32, No.
Psychology, Amsterdam UMC, Vrije Universiteit Amsterdam, 11 (34564728) (0 citations)
Amsterdam Neuroscience, VUmc Cancer Center Amsterdam
Brain Tumor Center Amsterdam, 1081 HV, Amsterdam, the
Netherlands; Stichting Epilepsie Instellingen Nederland (SEIN),

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