Page 169 - MEGIN Book Of Abstracts - 2023

Delhi, India; MEG Facility, National Brain Research Institute, CONCLUSION Magnetic source imaging yields addi-
Manesar, India; MEG Resource Facility, Collaborative Project tional useful information which can significantly alter as
Between AIIMS & NBRC, National Brain Research Center, well as improve the surgical strategy for persons with
Manesar, India; Neuroradiology, All India Institute of Medi- epilepsy.
cal Sciences, New Delhi, India; Nuclear Medicine, All India
Institute of Medical Sciences, New Delhi, India; Pathology, All Keywords: diagnostic added value, drug-resistant
India Institute of Medical Sciences, New Delhi, India; Biosta- epilepsy, electroencephalography, epilepsy, magnetoen-
tistics, All India Institute of Medical Sciences, New Delhi, India; cephalography
Neurosurgery, All India Institute of Medical Sciences, New
Delhi, India European journal of neurology (2021), Vol. 28, No. 9
(34124810) (1 citation)
BACKGROUND AND PURPOSE In presurgical evalua-
tion for epilepsy surgery, information is sourced from
various imaging modalities to accurately localize the Magnetic source imaging in presurgical evaluation
epileptogenic zone. Magnetoencephalography (MEG) is of paediatric focal drug-resistant epilepsy and its
a newer noninvasive technique for localization. Howev- predictive value of surgical outcome in lesional
er, there is limited literature to evaluate if MEG provides cases: A single-centre experience from South India
additional advantage over the conventional imaging (2021)
modalities in clinical decision making. The objective of
this study was to assess the diagnostic added value of Gautham, Bhargava; Abdulhak, Asheeb; Mundlamuri,
MEG in decision making before epilepsy surgery. Ravindranadh Chowdary; Narayanan, Mariyappa;
Jayabal, Velmurugan; Kenchaiah, Raghavendra;
METHOD This was a prospective observational study. Asranna, Ajay; Dawn, Bharath Rose; Jitender, Saini;
Patients underwent 3 h of recording in a MEG scanner, Nagaraj, Chandana; Mangalore, Sandhya; Karthik,
and the resulting localizations were compared with Kulanthaivelu; Sadashiva, Nishanth; Mahadevan, Anita;
other complimentary investigations. Added value of Rajeswaran, Jamuna; Kumar, Keshav; Arivazhagan,
MEG (considered separately from high-density elec- Arimappamagan; Rao, Malla Bhaskara; Sinha, Sanjib
troencephalography) was defined as the frequency of
cases in which (i) the information provided by magnetic MEG research Centre, NIMHANS, Hosur Road, Bangalore,
source imaging (MSI) avoided implantation of intracra- India; Department of Neurology, NIMHANS, Hosur Road,
nial electrodes and the patient was directly cleared for Bangalore, India; Department of Neuroimaging and Inter-
surgery, and (ii) MSI indicated additional substrates for ventional Radiology, NIMHANS, Hosur Road, Bangalore,
implantation of intracranial electrodes. Postoperative India; Department of Neurosurgery, NIMHANS, Hosur Road,
seizure freedom was used as the diagnostic reference Bangalore, India; Department of Neuropathology, NIM-
by which to measure the localizing accuracy of MSI. HANS, Hosur Road, Bangalore, India; Department of Clinical
Psychology, NIMHANS, Hosur Road, Bangalore, India; MEG
RESULTS A total of 102 patients underwent epilepsy research Centre, NIMHANS, Hosur Road, Bangalore, India;
surgery. MEG provided nonredundant information, Department of Neurology, NIMHANS, Hosur Road, Bangalore,
which contributed to deciding the course of surgery in India. Electronic address: [email protected]
33% of the patients, and prevented intracranial record-
ings in 19%. A total of 76% of the patients underwent OBJECTIVE This study aims to evaluate the utility of
surgical resection in sublobes concordant with MSI magnetoencephalography in presurgical planning and
localization, and the diagnostic odds ratio for good in predicting post-surgical seizure outcome.
(Engel I) outcome in these patients was 2.3 (95% con-
fidence interval 0.68, 7.86; p = 0.183) after long-term METHODS This study included a cohort of 231 children
follow-up of 36 months. (1-18 years) with focal drug-resistant epilepsy who

 ontents  Index 148
C