Page 173 - MEGIN Book Of Abstracts - 2023

tively) and healthy controls (6/23, 4/23, respectively). sion with spikes using the proposed method or the
HFSs in 80-250 Hz and 250-600 Hz were detected in dipole-fitting method.
patients (16/23, 11/23, respectively) but not in healthy
controls. A combination of HFOs and HFSs localized EZs RESULTS The experimental results showed that the po-
for 22 (22/23, 96%) patients. sitional accuracy of the proposed method was higher
than that of LCMV, DICS, and MUSIC for simulation data.
CONCLUSIONS The results indicate, for the first time, For clinical real MEG data, the positional accuracy of the
that HFSs are a newer and more specific biomarker proposed method was higher than that of dipole-fit-
than HFOs for localizing EZs because HFOs appeared in ting regardless of whether the time window was ripple
both epilepsy patients and healthy controls while HFSs window or spike window. Also, the positional accuracy
appeared only in epilepsy patients. of the ripple window was higher than that of the spike
window regardless of whether the source location
Keywords: Epilepsy, High frequency activity, High frequen- method was the proposed method or the dipole-fitting
cy spike, High-frequency oscillation, Magnetic Source method. For both shallow and deep sources, the pro-
Imaging, Magnetoencephalography posed method provided effective performance.

Seizure (2021), Vol. 89 (33975080) (0 citations) CONCLUSION Tucker estimation of MEG for source
imaging by ripple window is a promising approach
toward the presurgical evaluation of epileptics.
Magnetoencephalography for epileptic focus
localization based on Tucker decomposition with Keywords: MEG, focal epileptic, higher-order orthogonal
ripple window (2021) iteration, ripple, source imaging, tucker decomposition

Shi, Li-Juan; Wei, Bo-Xuan; Xu, Lu; Lin, Yi-Cong; Wang, CNS neuroscience & therapeutics (2021), Vol. 27, No. 7
Yu-Ping; Zhang, Ji-Cong (33942534) (0 citations)

Beijing Advanced Innovation Centre for Biomedical Engi-
neering, Beihang University, Beijing, China; Hefei Innovation Recent Advances in Neuroimaging of Epilepsy
Research Institute, Beihang University, Hefei, Anhui, China; (2021)
Brain Functional Disease and Neuromodulation of Beijing
Key Laboratory, Beijing, China Goodman, Adam M; Szaflarski, Jerzy P

AIMS To improve the Magnetoencephalography (MEG) Department of Neurology, UAB Epilepsy Center, University of
spatial localization precision of focal epileptic. Alabama At Birmingham, 312 Civitan International Research
Center, Birmingham, AL, 35294, USA. [email protected]
METHODS 306-channel simulated or real clinical MEG
is estimated as a lower-dimensional tensor by Tucker ABSTRACT Human neuroimaging has had a major
decomposition based on Higher-order orthogonal impact on the biological understanding of epilepsy
iteration (HOOI) before the inverse problem using lin- and the relationship between pathophysiology, seizure
early constraint minimum variance (LCMV). For simulat- management, and outcomes. This review highlights
ed MEG data, the proposed method is compared with notable recent advancements in hardware, sequences,
dynamic imaging of coherent sources (DICS), multiple methods, analyses, and applications of human neuro-
signal classification (MUSIC), and LCMV. For clinical real imaging techniques utilized to assess epilepsy. These
MEG of 31 epileptic patients, the ripples (80-250 Hz) structural, functional, and metabolic assessments
were detected to compare the source location preci- include magnetic resonance imaging (MRI), positron
emission tomography (PET), and magnetoencephalog-

 ontents  Index 152
C