Page 175 - MEGIN Book Of Abstracts - 2023

in optimal vs. suboptimal outcome patients (p < 0.001); management of children with DRE by directing place-
their proximity to resection was correlated to outcome ment of intracranial electrodes thereby enhancing their
(p < 0.001). No difference in resection percentage was yield. With improved identification of a circumscribed
seen for scattered dipoles between groups. epileptogenic zone, MEG could render more patients as
suitable candidates for epilepsy surgery and increase
CONCLUSION MSI and ESI dipole clustering helps to utilization of surgery.
localize the SOZ and IZ and facilitate the prognostic as-
sessment of MRI-negative patients with DRE. Keywords: Drug-resistant epilepsy, eloquent cortex map-
ping, epilepsy surgery evaluation, epileptogenic zone,
SIGNIFICANCE Assessing the MSI and ESI clustering magnetoencephalography
allows recognizing epileptogenic areas whose removal
is associated with optimal outcome. Expert review of neurotherapeutics (2021), Vol. 21, No. 11
(33780318) (1 citation)
Keywords: Dipole clusterness, Electric source imaging,
Epilepsy surgery, Localization, Magnetic source imaging,
Negative MRI Pediatric Epilepsy Surgery: Indications and
Evaluation (2021)
Clinical neurophysiology: official journal of the
International Federation of Clinical Neurophysiology Madaan, Priyanka; Gupta, Ajay; Gulati, Sheffali
(2022), Vol. 141 (33875376) (9 citations)
Pediatric Neurology Unit, Department of Pediatrics, Post
Graduate Institute of Medical Education and Research, Chan-
A review of magnetoencephalography use in digarh, India; Pediatric Epilepsy, Epilepsy Center, Department
pediatric epilepsy: an update on best practice of Neurology/Neurological Institute, Cleveland Clinic Lerner
(2021) College of Medicine, Cleveland Clinic, 9500 Euclid Avenue,
Cleveland, OH, 44195, USA; Center of Excellence & Advanced
Otsubo, Hiroshi; Ogawa, Hiroshi; Pang, Elizabeth; Wong, Research on Childhood Neurodevelopmental Disorders,
Simeon M; Ibrahim, George M; Widjaja, Elysa Child Neurology Division, Department of Pediatrics, All India
Institute of Medical Sciences, New Delhi, 110029, India. shef-
Diagnostic Imaging, Hospital for Sick Children, Toronto, [email protected]
Canada; Neuroscience and Mental Health, Hospital for Sick
Children, Toronto, Canada; Diagnostic Imaging, Hospital for ABSTRACT Epilepsy is a common neurological condi-
Sick Children, Toronto, Canada tion in children. It is usually amenable to drug therapy.
However, nearly one-third of patients may be refractory
ABSTRACT Introduction: Magnetoencephalography to antiseizure drugs. Poor compliance and nonepileptic
(MEG) is a noninvasive technique that is used for events should be ruled out as possible causes of drug-
presurgical evaluation of children with drug-resistant resistant epilepsy (DRE). After failing adequate trials of
epilepsy (DRE).Areas covered: The contributions of MEG two appropriate antiseizure drugs, patients with focal
for localizing the epileptogenic zone are discussed, in DRE or poorly classifiable epilepsy or epileptic en-
particular in extra-temporal lobe epilepsy and focal cor- cephalopathy with focal electro-clinical features should
tical dysplasia, which are common in children, as well as be worked up for surgical candidacy. A randomized
in difficult to localize epilepsy such as operculo-insular controlled trial provided a class I evidence for epi-
epilepsy. Further, the authors review current evidence lepsy surgery in pediatric DRE. Pre-surgical screening
on MEG for mapping eloquent cortex, its performance, workup typically includes a high-resolution epilepsy
application in clinical practice, and potential chal- protocol brain magnetic resonance imaging (MRI)
lenges.Expert opinion: MEG could change the clinical and a high-quality in-patient video electroencepha-

 ontents  Index 154
C