Page 180 - MEGIN Book Of Abstracts - 2023

Comparative contribution of % respectively. The diagnostic odds ratio for Engel I
magnetoencephalography (MEG) and single- surgical outcome was reported as 2.43 and 5.0 for MEG
photon emission computed tomography (SPECT) in and SPECT respectively. The diagnostic odds ratio for
pre-operative localization for epilepsy surgery: A MEG in whom SPECT was non-informative was found to
prospective blinded study (2021) be 6.57 [95 % CI 1.1, 39.24], although it was not signifi-
cantly associated with good surgical outcome. MEG
Kaur, Kirandeep; Garg, Ajay; Tripathi, Madhavi; Chandra, was useful in indicating sites for SEEG implantation.
Sarat P; Singh, Gaurav; Viswanathan, Vibhin; Bharti,
Kamal; Singh, Vivek; Ramanujam, Bhargavi; Bal, Chandra CONCLUSION SPECT was found to be non-informative
Sekhar; Sharma, Mehar Chand; Pandey, Ravindra; Vibha, for most patients, but reported better diagnostic
Deepti; Singh, Rajesh Kumar; Mandal, Pravat Kumar; output than MEG. MEG may be a useful alternative for
Tripathi, Manjari patients in whom SPECT cannot be done or was non-
localizing.
Dept of Neurology, All India Institute of Medical Sciences, New
Delhi, India; MEG Facility, National Brain Research Institute, Keywords: Epilepsy, Epilepsy surgery, Magnetoencepha-
Manesar, India; Dept of Neuroradiology, All India Institute of lography (MEG), Neuroimaging, Single-photon emission
Medical Sciences, New Delhi, India; Dept of Nuclear Medicine, computed tomography (SPECT)
All India Institute of Medical Sciences, New Delhi, India; Dept
of Neurosurgery, All India Institute of Medical Sciences, New Seizure (2021), Vol. 86 (33647809) (6 citations)
Delhi, India; Dept of Pathology, All India Institute of Medical
Sciences, New Delhi, India; Dept of Biostatistics, All India Insti-
tute of Medical Sciences, New Delhi, India; Dept of Neurol- Interictal spike localization for epilepsy surgery
ogy, All India Institute of Medical Sciences, New Delhi, India. using magnetoencephalography beamforming
Electronic address: [email protected] (2021)

PURPOSE The aim of this study was to compare the Li, Rui; Plummer, Chris; Vogrin, Simon J; Woods, William
diagnostic value and accuracy of ictal SPECT and inter- P; Kuhlmann, Levin; Boston, Ray; Liley, David T J; Cook,
ictal magnetoencephalography (MEG) in localizing the Mark J; Grayden, David B
site for surgery in persons with drug resistant epilepsy.
Department of Biomedical Engineering, The University of
METHOD This was a prospective observational study. Melbourne, Parkville, VIC, Australia. Electronic address: ruil3@
Patients expected to undergo epilepsy surgery were student.unimelb.edu.au; Department of Medicine, The
enrolled consecutively and the localization results from University of Melbourne, Fitzroy, VIC, Australia; Department
different imaging modalities were discussed in an epi- of Neurology, St. Vincent's Hospital, Fitzroy, VIC, Australia;
lepsy surgery meet. Odds ratio of good outcome (Engel School of Health Sciences, Swinburne University of Tech-
I) were calculated in patients who underwent surgery nology, Hawthorn, VIC, Australia; Faculty of Information
in concordance with MEG and SPECT findings. Post- Technology, Monash University, Clayton, VIC 3168, Australia;
surgical seizure freedom lasting at least 36 months or Department of Medicine, The University of Melbourne, Fitzroy,
more was considered the gold standard for determin- VIC, Australia; Department of Clinical Studies, New Bolton
ing the diagnostic output of SPECT and MEG. Centre, School of Veterinary Medicine, University of Penn-
sylvania, Kennett Square, PA, USA; Department of Medicine,
RESULTS MEG and SPECT were performed in 101 and The University of Melbourne, Fitzroy, VIC, Australia; Centre
57 patients respectively. In 45 patients SPECT could for Human Psychopharmacology, Swinburne University
not be done due to delay in injection or technical fac- of Technology, Hawthorn, VIC, Australia; Department of
tors. The accuracy of MEG and SPECT in localizing the Medicine, The University of Melbourne, Fitzroy, VIC, Australia;
epileptogenic zone was found to be 74.26 % and 78.57 Department of Neurology, St. Vincent's Hospital, Fitzroy, VIC,

 ontents  Index 159
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