Page 183 - MEGIN Book Of Abstracts - 2023

co-registration can greatly improve the identification of time of 4.9 years. In detail, 80% of lesional cases were
epileptic abnormalities, which can be used as surgi- seizure free compared to 59% of MRI negative patients.
cal target. MAP and PET/MRI co-registration should be Localizing MEG spike activity in the vicinity of the
incorporated into the routine presurgical evaluation. first resection cavity was present in 12 of 27 patients
(44%) corresponding to 83% (10/12) of MEG localizing
Keywords: Cingulate epilepsy, Focal cortical dysplasia, spike patients having advanced seizure outcome after
Invasive electroencephalography, Magnetic resonance operative revision.Conclusion: Re-operation after failed
imaging, Magnetoencephalography, Morphometric surgery in refractory epilepsy may lead to a better
analysis program, PET/MRI co-registration seizure outcome in the majority of patients. Preopera-
tive MEG may support the decision for surgery and may
Epilepsy research (2021), Vol. 171 (33610065) (4 citations) facilitate targeting epileptogenic tissue for re-resection
by employing navigation and iopMR imaging.

Advantages of magnetoencephalography, Keywords: Failed epilepsy surgery, MEG, intraoperative MR
neuronavigation and intraoperative MRI in epilepsy imaging, neuronavigation, reoperation, seizure outcome
surgery re-operations (2021)
Neurological research (2021), Vol. 43, No. 6 (33402062) (2
Shawarba, Julia; Kaspar, Burkhard; Rampp, Stefan; citations)
Winter, Fabian; Coras, Roland; Blumcke, Ingmar; Hamer,
Hajo; Buchfelder, Michael; Roessler, Karl
Succinic Semialdehyde Dehydrogenase Deficiency:
Neurosurgical Department, Erlangen University Clinic, Erlan- Review of the Natural History Study (2021)
gen, Germany; Neurological Department, Erlangen University
Clinic, Erlangen, Germany; Neurosurgical Clinic, Vienna Medi- Pearl, Phillip L; DiBacco, Melissa L; Papadelis, Christos;
cal University, Vienna, Austria; Neuropathological Institute, Opladen, Thomas; Hanson, Ellen; Roullet, Jean-Baptiste;
Erlangen University Clinic, Erlangen, Germany Gibson, K Michael

ABSTRACT Objective: Management of patients after Department of Neurology, Boston Children's Hospital,
failed epilepsy surgery is still challenging. Advanced Harvard Medical School, Boston, MA, USA; Laboratory of Chil-
diagnostic and intraoperative tools including magneto- dren's Brain Dynamics, Division of Newborn Medicine, Boston
encephalography (MEG) as well as neuronavigation and Children's Hospital, Harvard Medical School, Boston, MA, USA;
intraoperative magnetic resonance imaging (iopMRI) Department of Child Neurology and Metabolic Disorders,
may contribute to a better postoperative seizure University Children's Hospital, Heidelberg, Germany; Neu-
outcome in this patient group.Methods: We retrospec- rodevelopmental Core, Boston Children's Hospital, Harvard
tively analyzed consecutive patients after reopera- Medical School, Boston, MA, USA; Department of Pharmaco-
tion of failed epilepsy surgery for medically refractory therapy, Washington State University, Spokane, WA, USA
epilepsy at the University of Erlangen between 1988
and 2017. Inclusion criteria for patients were available OBJECTIVE The SSADHD Natural History Study was ini-
MEG, neuronavigation and iopMRI data. The Engel scale tiated in 2019 to define the natural course and identify
was used to categorize seizure outcome.Results: We biomarkers correlating with severity.
report on 27 consecutive patients (13 female/14 male
mean age at first surgery 29.4 years) who had opera- METHODS The study is conducted by 4 institutions:
tive revision of the first resection after failed epilepsy BCH (US clinical), WSU (bioanalytical core), USF (bio-
surgery. An improved seizure outcome postoperatively statistical core), and Heidelberg (iNTD), with support
was observed in 78% of patients (p < 0.001) with 55% from the family advocacy group (SSADH Association).
seizure free (Engel I) patients after a mean follow-up

 ontents  Index 162
C