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P300 in mesial temporal lobe epilepsy and HS), visual P300 amplitudes were lower in the right HS
its correlation with cognition - A MEG based group compared to both left HS and control groups (p-
prospective case-control study (2021) value = 0.014). On the other hand, no significant differ-
ence for auditory P300 latency or amplitude was noted
Mukheem Mudabbir, M A; Mundlamuri, Ravindranadh between patients and controls as well as between
Chowdary; Mariyappa, Narayanan; Aravind Kumar, subgroups. A negative correlation found between the
Rajasekaran; Velmurugan, Jayabal; Bhargava, G MEG visual P300 amplitude and Indian Trial Making Test
K; Suvarna, Alladi; Shivashankar, N; Raghavendra, (TMT)-B duration in the patient group.
Kenchaiah; Asranna, Ajay; Thennarasu, K; Jamuna,
Rajeswaran; Rose Dawn, Bharath; Saini, Jitender; Sinha, CONCLUSION Patients with TLE-HS have decreased
Sanjib visual-P300 amplitude. A significant correlation found
between visual P300 amplitude and cognitive tests
Department of Neurology, NIMHANS, Bangalore 560029, of visuospatial attention and working memory. Over-
India; Department of Speech Pathology and Audiology, all, MEG based visual P300 amplitude can be further
NIMHANS, Bangalore 560029, India; Department of Biosta- explored with large sample size studies to establish as a
tistics, NIMHANS, Bangalore 560029, India; Department of complementary objective test for cognitive assessment
Clinical Psychology, NIMHANS, Bangalore 560029, India; in TLE.
Department of Neuro-Imaging and Interventional Radiology,
NIMHANS, Bangalore 560029, India; Department of Neurol- Keywords: CLARA, Event related field, ICA, Magnetoen-
ogy, NIMHANS, Bangalore 560029, India. Electronic address: cephalography, P300, Temporal lobe epilepsy
[email protected]
Epilepsy & behavior: E&B (2021), Vol. 114, No. Pt A
PURPOSE To assess the role of P300 in patients with (33248942) (3 citations)
temporal lobe epilepsy (TLE) with unilateral hippo-
campal sclerosis (HS) using magnetoencephalography
(MEG) based auditory and visual oddball tasks, and to Contributions of electrophysiology for identifying
assess its correlation with neuropsychological tests. cortical language systems in patients with epilepsy
(2020)
METHODS Thirty-patients (M:F-17:13, on-
set-11.77 ± 8.75 years, duration-16.10 ± 9.61 years) with Trébuchon, Agnès; Liégeois-Chauvel, Catherine;
TLE-HS (Left:15, Right:15) and fifteen-healthy age, gen- Gonzalez-Martinez, Jorge A; Alario, F-Xavier
der and years of education matched controls (M:F-10:5,
age-28.13 ± 4.76 years) underwent auditory and visual Aix-Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille,
oddball tasks in MEG and cognition assessment using France; Aix-Marseille Univ, INSERM, INS, Inst Neurosci Syst,
Indian Council of Medical Research (ICMR)-cognitive Marseille, France; Department of Neurological Surgery,
test battery. Independent component analysis (ICA) School of Medicine, University of Pittsburgh (PA), USA;
was applied to the magnetic evoked field responses for Department of Neurological Surgery, School of Medicine,
the detection of the P300 component. Source local- University of Pittsburgh (PA), USA; Aix-Marseille Univ, CNRS,
ization of P300 was performed with Classical LORETA LPC, Marseille, France. Electronic address: [email protected]
Analysis Recursively Applied (CLARA). The latency and
amplitude of P300 were estimated and subsequently ABSTRACT A crucial element of the surgical treat-
correlated with cognitive scores. ment of medically refractory epilepsy is to delineate
cortical areas that must be spared in order to avoid
RESULTS The visual P300 amplitude in the TLE group clinically relevant neurological and neuropsychological
was lower when compared to the control group. In deficits postoperatively. For each patient, this typically
subgroup comparison (controls vs. right HS vs. left necessitates determining the language lateraliza-

 ontents  Index 166
C