Page 192 - MEGIN Book Of Abstracts - 2023

eters, as well as improved post processing of the data Krembil Brain Institute, University of Toronto, University
during interictal and ictal activity for accurate source Health Network, Toronto Western Hospital, Toronto, Can-
localisation of the epileptogenic focus. These advances ada. Electronic address: [email protected]; Klinik
should broaden the scope of MEG as an important part Hirslanden, Zürich, Switzerland
of epilepsy diagnostics in the future.
OBJECTIVE Benign epileptiform transients of sleep
Keywords: OPMs, electroencephalograph, magnetoen- (BETS) have a unique voltage topography and a pos-
cephalography, source localisation teriorly propagating, inferiorly rotating diphasic EEG
pattern. The source generators of BETS have not been
Seizure (2020), Vol. 83 (33096459) (0 citations) definitively identified. We aimed to clarify the cerebral
localization of BETS using MEG and electromagnetic
source imaging (EMSI).
Bridging the gap between analytical methods and
their clinical interpretation (2020) METHODS We analyzed BETS recorded with simul-
taneous MEG and EEG in four patients with epilepsy.
Kaur, Kirandeep; Chandra, Poodepedi Sarat; Samala, Magnetic source imaging (MSI) and EMSI using equiva-
Raghu; Agrawal, Mohit; Doddamani, Ramesh; lent current, single moving and rotating dipole inverse
Ramanujam, Bhargavi; Singh, Gaurav; Tripathi, Manjari models was performed on averaged BETS potentials.
MEG beamforming was performed in one case with
MEG Facility, National Brain Research Centre, Manesar, India; abundant BETS.
Department of Neurosurgery, All India Institute of Medical
Sciences (AIIMS), New Delhi, India; Department of Neurol- RESULTS MSI and EMSI revealed hippocampal dipole
ogy, All India Institute of Medical Sciences (AIIMS), New Delhi, source maxima in all cases, with current flow direc-
India tion rotating from inferomedial to superomedial or
superolateral between the first and second BETS peaks.
Epilepsia (2020), Vol. 61, No. 11 (33063844) (0 citations) Moving dipole analyses revealed spatiotemporal
propagation along the anterior-posterior hippocampal
axis and concomitant electromagnetic field rotation.
Multidimensional analytical methods and their Beamformer source reconstruction revealed an identi-
clinical interpretation (2020) cal hippocampal localization.

Wong, Simeon M; Ibrahim, George M CONCLUSIONS Converging evidence from different
electromagnetic inverse modeling methods indicates
Institute of Biomaterials and Biomedical Engineering, Univer- that BETS are traveling, rotating hippocampal spikes,
sity of Toronto, Toronto, Ontario, Canada; Institute of Medical whose diphasic waveform is due to back and forth
Science, University of Toronto, Toronto, Ontario, Canada propagation along the anterior-posterior axis of the
hippocampus.
Epilepsia (2020), Vol. 61, No. 11 (33063843) (0 citations)
SIGNIFICANCE The hippocampal localization and lon-
gitudinal, rotating propagation pattern of BETS raises
Electromagnetic evidence that benign epileptiform the possibility of a sleep-related functional role for
transients of sleep are traveling, rotating these hippocampal spikes.
hippocampal spikes (2020)

Wennberg, Richard; Tarazi, Apameh; Zumsteg, Dominik;
Garcia Dominguez, Luis

 ontents  Index 171
C