Page 194 - MEGIN Book Of Abstracts - 2023

evoked magnetic fields (SEFs) evoked by median nerve Edition (WISC-IV). Magnetoencephalographic (MEG)
stimulation were recorded in each hemisphere of 15 data of 18 healthy children and 22 BECTS patients were
TLE patients and 28 normal subjects. All responses were recorded in order to construct a functional connectiv-
separately averaged in the awake state and light sleep ity (FC) network, which was quantified by graph theory
using background magnetoencephalography. Latency (GT).
and strength of the equivalent current dipole (ECD)
was compared between the groups for the first (M1) RESULTS The mean age of the control group was
and second peaks. Latencies showed no significant 7.94 ± 1.89 years, and the mean age of BECTS patients
differences between the groups in either wakefulness was 8.14 ± 1.73 years. Our results show that the WISC-
or light sleep. ECD strengths were significantly lower in IV index scores in the BECTS group were significantly
TLE patients than in controls only during wakefulness. lower than those in the control group. Besides, the FC
The reduction of M1 ECD strength in the awake state is network pattern of BECTS patients changed significant-
significantly correlated with duration of epilepsy. SEFs ly in the 12-30, 30-80, and 250-500 Hz frequency band.
of TLE patients showed pure ECD strength reduction The local functional connections between posterior
without latency delay. The phenomenon occurred cingulate cortex (PCC) and frontal lobe varied signifi-
exclusively during wakefulness, suggesting that a cantly in 12-30, 80-250, and 250-500 Hz. Our GT analysis
wakefulness-specific modulator of S1 is abnormal in shows that the connection strength of BECTS patients
TLE. Repetitive seizures may gradually insult the modu- increases significantly in the 12-30 Hz frequency band,
lator of S1 distant from the epileptogenic network. the path length decreases significantly in the 12-30 Hz
and 30-80 Hz frequency bands, with the clustering
Scientific reports (2020), Vol. 10, No. 1 (32985579) (1 coefficient decreasing significantly in the 12-30 Hz,
citation) 30-80 Hz, and 250-500 Hz frequency bands. Correlation
analysis showed that the full-scale IQ (FSIQ) was posi-
tively correlated with the 12-30 Hz clustering coeffi-
The relationship between epilepsy and cognitive cient, verbal comprehension index (VCI) was positively
function in benign childhood epilepsy with correlated with the 250-500 Hz clustering coefficient,
centrotemporal spikes (2020) perceptual reasoning index (PRI) was positively corre-
lated with the 12-30 Hz clustering coefficient, and per-
Li, Yihan; Sun, Yulei; Zhang, Tingting; Shi, Qi; Sun, Jintao; ceptual reasoning index (PSI) was negatively correlated
Xiang, Jing; Chen, Qiqi; Hu, Zheng; Wang, Xiaoshan with the 12-30 Hz path length.

Department of Neurology, Nanjing Brain Hospital, Nanjing CONCLUSION There is a trend of cognitive impairment
Medical University, Nanjing, China; MEG Center, Division of in patients with early BECTS. This trend of cognitive
Neurology, Cincinnati Children's Hospital Medical Center, impairment in early BECTS children may be related to
Cincinnati, OH, USA; MEG Center, Nanjing Brain Hospital, the changes in the FC network pattern.
Nanjing, China; Department of Neurology, Nanjing Children's
Hospital, Nanjing, China Keywords: benign childhood epilepsy with centrotempo-
ral spikes, functional connectivity, graph theory, magneto-
INTRODUCTION This study was aimed to explore the encephalography, multi-frequency, neural network
relationship between neural network changes in newly
diagnosed children with Benign Childhood Epilepsy Brain and behavior (2020), Vol. 10, No. 12 (32959999) (9
with Centrotemporal Spikes (BECTS) and cognitive citations)
impairment.

METHODS Children's cognition was evaluated using
the Wechsler Intelligence Scale for Children-Fourth

 ontents  Index 173
C