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netoencephalography examination is the magnetoen- ABSTRACT Source localization for clinical magneto-
cephalography laboratory's most important product encephalography recordings is challenging, and many
and is a representation of the quality of the laboratory methods have been developed to solve this inverse
and the clinical acumen of the personnel. A magneto- problem. The most well-studied and validated tool for
encephalography report is not meant to enumerate all localization of the epileptogenic zone is the equivalent
the technical details that went into the test nor to fulfill current dipole. However, it is often difficult to summa-
some imagined requirements of the electronic health rize the richness of the magnetoencephalography data
record. It is meant to clearly and concisely answer the with one or a few point sources. A variety of source
clinical question posed by the referring doctor and to localization algorithms have been developed to more
convey the key findings that may inform the next step fully explain the complexity of clinical magnetoenceph-
in the patient's care. The graphical component of a alography data used to define the epileptogenic net-
magnetoencephalography report is ordinarily the most work. In this review, various clinically available source
welcomed by the referring doctor. Much of the text localization methods are described and their individual
of the report may be glossed over, so the illustrations strengths and limitations are discussed.
must be sufficiently annotated to provide clear and
unambiguous findings. The particular images chosen Journal of clinical neurophysiology: official publication
for the report will be a function of the analysis software of the American Electroencephalographic Society (2020),
but should be selected and edited for maximum clarity. Vol. 37, No. 6 (33165226) (8 citations)
There should be a composite pictorial summary slide
at the beginning or at the end of the report, which
accurately conveys the gist of the report. Along with Normal Variants in Magnetoencephalography
representative source localizations, reports should con- (2020)
tain examples of the simultaneously recorded EEG that
enable the referring physician to determine whether Rampp, Stefan; Kakisaka, Yosuke; Shibata, Sumiya; Wu,
epileptic discharges occurred and whether they are Xingtong; Rössler, Karl; Buchfelder, Michael; Burgess,
consistent with the patient's previously recorded Richard C
spikes. Information and images (e.g., statistics, mag-
netic field patterns) that provide convincing evidence Department of Neurosurgery, University Hospital, Halle (Saa-
of the validity of the source location should also be le), Germany; Department of Epileptology, Tohoku University
included. School of Medicine, Sendai, Japan; Department of Neuro-
surgery and Human Brain Research Center, Kyoto University
Journal of clinical neurophysiology: official publication Graduate School of Medicine, Kyoto, Japan; Department of
of the American Electroencephalographic Society (2020), Neurology, West China Hospital, Sichuan University, Sichuan,
Vol. 37, No. 6 (33165227) (3 citations) China; and; Department of Neurosurgery, University Hospital,
Erlangen, Germany; Epilepsy Center, Cleveland Clinic, Cleve-
land, Ohio, U.S.A
The Value of Source Localization for Clinical
Magnetoencephalography: Beyond the Equivalent ABSTRACT Normal variants, although not occurring
Current Dipole (2020) frequently, may appear similar to epileptic activity.
Misinterpretation may lead to false diagnoses. In the
Tenney, Jeffrey R; Fujiwara, Hisako; Rose, Douglas F context of presurgical evaluation, normal variants
may lead to mislocalizations with severe impact on
Division of Neurology, Cincinnati Children's Hospital Medical the viability and success of surgical therapy. While the
Center, Cincinnati, Ohio, U.S.A different variants are well known in EEG, little has been
published in regard to their appearance in magne-
toencephalography. Furthermore, there are some
ontents Index 169
C