Page 177 - MEGIN Book Of Abstracts - 2023

SIGNIFICANCE We confirmed the causative roles CONCLUSIONS The results indicate, for the first time,
played by TTTTA/TTTCA repeat expansion in the that epileptic HFBS can be noninvasively quantified by
SAMD12 gene in FCTME1. Both the length and the con- measuring kurtosis and skewness in MEG data. Mag-
figuration of the repeats contribute to the clinical and netic source imaging based on kurtosis and skewness
neurophysiological characteristics of the disease. can accurately localize EZs.

Keywords: Clinical features, Electrophysiological changes, SIGNIFICANCE Source imaging of kurtosis and skew-
FCMTE1, Genetic study, TTTTA/TTTCA configurations ness of MEG HFBS provides a novel way for preopera-
tive localization of EZs for epilepsy surgery.
Seizure (2021), Vol. 87 (33721773) (5 citations)
Keywords: Epilepsy, High frequency brain signals, Kurtosis,
Magnetic source imaging, Magnetoencephalography,
Delineation of epileptogenic zones with high Skewness
frequency magnetic source imaging based on
kurtosis and skewness (2021) Epilepsy research (2021), Vol. 172 (33713889) (0 citations)

Xiang, Jing; Maue, Ellen; Fujiwara, Hisako; Mangano,
Francesco T; Greiner, Hansel; Tenney, Jeffrey Noninvasive Mapping of Ripple Onset Predicts
Outcome in Epilepsy Surgery (2021)
MEG Center, Cincinnati Children's Hospital Medical Center,
Cincinnati, OH, USA; Division of Neurology, Cincinnati Chil- Tamilia, Eleonora; Matarrese, Margherita A G;
dren's Hospital Medical Center, Cincinnati, OH, USA. Electron- Ntolkeras, Georgios; Grant, P Ellen; Madsen, Joseph R;
ic address: [email protected]; Division of Neurosurgery, Stufflebeam, Steve M; Pearl, Phillip L; Papadelis, Christos
Cincinnati Children's Hospital Medical Center, Cincinnati, OH,
USA Fetal-Neonatal Neuroimaging and Developmental Science
Center, Boston Children's Hospital, Harvard Medical School,
BACKGROUND Neuromagnetic high frequency brain Boston, MA; Laboratory of Nonlinear Physics and Math-
signals (HFBS, > 80 Hz) are a new biomarker for localiza- ematical Modeling, Department of Engineering, University
tion of epileptogenic zones (EZs) for pediatric epilepsy. Bio-Medico Campus of Rome, Rome, Italy; Epilepsy Surgery
Program, Department of Neurosurgery, Boston Children's
METHODS Twenty three children with drug-resistant Hospital, Harvard Medical School, Boston, MA; Athinoula
epilepsy and age/sex matched healthy controls were A. Martinos Center for Biomedical Imaging, Massachusetts
studied with magnetoencephalography (MEG). Epi- General Hospital, Harvard Medical School, Boston, MA; Divi-
leptic HFBS in 80-250 Hz and 250-600 Hz were quan- sion of Epilepsy and Clinical Neurophysiology, Department
titatively determined by comparing with normative of Neurology, Boston Children's Hospital, Harvard Medical
controls in terms of kurtosis and skewness. Magnetic School, Boston, MA; Department of Bioengineering, Univer-
sources of epileptic HFBS were localized and then com- sity of Texas at Arlington, Arlington, TX
pared to clinical EZs determined by invasive recordings
and surgical outcomes. OBJECTIVE Intracranial electroencephalographic
(icEEG) studies show that interictal ripples propagate
RESULTS Kurtosis and skewness of HFBS were sig- across the brain of children with medically refractory
nificantly elevated in epilepsy patients compared to epilepsy (MRE), and the onset of this propagation
healthy controls (p < 0,001 and p < 0.0001, respective- (ripple onset zone [ROZ]) estimates the epileptogenic
ly). Sources of elevated MEG signals in comparison to zone. It is still unknown whether we can map this
normative data were co-localized to EZs for 22 (22/23, propagation noninvasively. The goal of this study is
96 %) patients. to map ripples (ripple zone [RZ]) and their propaga-

 ontents  Index 156
C