Page 170 - MEGIN Book Of Abstracts - 2023

underwent MEG as a part of their presurgical workup. Heritability of Magnetoencephalography
Characteristics of MEG observations were described in Phenotypes Among Patients With Genetic
all children. The concordance and agreement of Mag- Generalized Epilepsy and Their Siblings (2021)
netic Source Imaging (MSI) of interictal discharges (IED)
was estimated with either of the 3 subgroups - MRI Stier, Christina; Elshahabi, Adham; Li Hegner, Yiwen;
lesion; presumed epileptogenic zone (EZ); or resection Kotikalapudi, Raviteja; Marquetand, Justus; Braun,
cavity. In operated children group, MEG dipole charac- Christoph; Lerche, Holger; Focke, Niels K
teristics between good and poor outcome groups were
assessed. From the Clinic of Clinical Neurophysiology (C.S., R.K.,
N.K.F.), University Medical Center Göttingen; Department of
RESULTS A total of 153 cases (66.2%) showed frequent Neurology and Epileptology, Hertie Institute of Clinical Brain
IEDs (60 spikes/60 min). Of the 173 cases where MSI Research (C.S., A.E., Y.L.H., R.K., J.M., H.L., N.K.F., C.B.), and MEG
showed clusters (74.9%), 151 had lesions and 22 were Center (C.B.), University of Tübingen, Germany; Department
non-lesional. amongst patients with lesional epilepsy of Neurology (A.E.), University Hospital Zurich; Institute of
and MEG clusters, class I concordance (MEG localiza- Psychology (R.K.), University of Bern, Switzerland; and CIMeC
tion either completely included or overlapped at least (C.B.), Center for Mind/Brain Sciences, University of Trento,
60% with the MRI lesion) was seen in 60.92% with a Italy; From the Clinic of Clinical Neurophysiology (C.S., R.K.,
Cohen's kappa of 0.608. In non-lesional epilepsy, class N.K.F.), University Medical Center Göttingen; Department of
I concordance of MEG with presumed EZ was found Neurology and Epileptology, Hertie Institute of Clinical Brain
in (81.81%) with an agreement of 0.317. Fifty-three Research (C.S., A.E., Y.L.H., R.K., J.M., H.L., N.K.F., C.B.), and MEG
children underwent surgery of whom 39 (73.58%) Center (C.B.), University of Tübingen, Germany; Department
showed a good outcome (Engel I). In operated children, of Neurology (A.E.), University Hospital Zurich; Institute of
concordance between MEG focus and resection cavity Psychology (R.K.), University of Bern, Switzerland; and CIMeC
was observed in 23 (58.97%) with good outcome and (C.B.), Center for Mind/Brain Sciences, University of Trento,
in 12 (86.72%) with poor outcome with no significant Italy. [email protected]
difference (p>0.05). However, MEG cluster regular or-
ganization and clusterectomy are associated with good OBJECTIVE To assess whether neuronal signals in
seizure outcome postoperatively (p< 0.05). Presence of patients with genetic generalized epilepsy (GGE) are
scatters were associated with poor outcome (p<0.05) in heritable, we examined magnetoencephalography
children with focal cortical dysplasia. resting-state recordings in patients and their healthy
siblings.
CONCLUSIONS MEG provides useful information that
can serve as a biomarker for prognosticating the surgi- METHODS In a prospective, cross-sectional design, we
cal outcome in paediatric epilepsy. Cluster removal and investigated source-reconstructed power and function-
regular cluster organization shows predictive power in al connectivity in patients, siblings, and controls. We
post-surgical prognostication in children and the pres- analyzed 5 minutes of cleaned and awake data without
ence of scatters predicts poor outcome in children with epileptiform discharges in 6 frequency bands (1-40 Hz).
focal cortical dysplasia. We further calculated intraclass correlations to estimate
heritability for the imaging patterns within families.
Keywords: Drug resistant epilepsy, Magnetoencephalog-
raphy (MEG), Paediatric epilepsy surgery RESULTS Compared with controls (n = 45), patients
with GGE (n = 25) showed widespread increased func-
Seizure (2021), Vol. 91 (34058605) (0 citations) tional connectivity (θ to γ frequency bands) and power
(δ to γ frequency bands) across the spectrum. Siblings
(n = 18) fell between the levels of patients and controls.
Heritability of the imaging metrics was observed in

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