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networks of TLE patients displayed abnormally high METHODS We retrospectively reviewed simultane-
synchronization in multi-frequency bands and shifted ous scalp EEG and MEG recordings of 83 consecutive
toward a more regular architecture with worse network patients with TLE and 49 with extra-TLE (ETLE).
efficiency in the theta band. Without the contamination
of structural lesions, these significant findings can be RESULTS SSSs in scalp EEG were detected in 15 (18.1%)
helpful for better understanding of the pathophysi- of 83 TLE patients compared to only two (4.1%) of 49
ological mechanism of TLE. The theta band can be ETLE patients (p = 0.029). Five of the 15 TLE patients
considered as a preferred frequency band for investi- had MEG spikes with concurrent SSSs in EEG, but nei-
gating the brain-network dysfunction of MRI-negative ther of the 2 ETLE patients. Three of these 5 TLE patients
intractable TLE patients. had additional interictal epileptiform discharges (IEDs)
in EEG and MEG. Equivalent current dipoles (ECDs) of
Keywords: Brain network, Functional connectivity, Graph MEG spikes with concurrent SSSs and IEDs showed no
theory, MRI-negative, Magnetoencephalography, Tempo- difference in temporal lobe localization and horizontal
ral lobe epilepsy orientation, whereas ECD moments were smaller in
MEG spikes with concurrent SSSs than those with IEDs.
Brain topography (2021), Vol. 34, No. 5 (34173926) (3
citations) CONCLUSIONS SSSs were more common in TLE than
in ETLE. At least some morphologically diagnosed SSSs
are true but low-amplitude epileptiform discharges in
Magnetoencephalography to confirm epileptiform TLE which can be identified with simultaneous MEG.
discharges mimicking small sharp spikes in
temporal lobe epilepsy (2021) SIGNIFICANCE Simultaneous MEG is useful to identify
epileptiform discharges mimicking SSSs in patients
Agari, Dai; Jin, Kazutaka; Kakisaka, Yosuke; Kanno, with TLE.
Akitake; Ishida, Makoto; Kawashima, Ryuta; Nakasato,
Nobukazu Keywords: Benign epileptiform transients of sleep, Mag-
netoencephalography, Small sharp spikes, Temporal lobe
Department of Epileptology, Tohoku University Graduate epilepsy
School of Medicine, Sendai, Miyagi, Japan; Department of
Collaborative Laboratory of Electromagnetic Neurophysiol- Clinical neurophysiology: official journal of the
ogy, Tohoku University Graduate School of Medicine, Sendai, International Federation of Clinical Neurophysiology
Miyagi, Japan; Department of Epileptology, Tohoku Univer- (2021), Vol. 132, No. 8 (34130246) (0 citations)
sity Graduate School of Medicine, Sendai, Miyagi, Japan;
Department of Collaborative Laboratory of Electromagnetic
Neurophysiology, Tohoku University Graduate School of Diagnostic added value of interictal magnetic
Medicine, Sendai, Miyagi, Japan. Electronic address: jink@ source imaging in presurgical evaluation of persons
med.tohoku.ac.jp; Institute of Development, Aging and Can- with epilepsy: A prospective blinded study (2021)
cer, Tohoku University, Sendai, Miyagi, Japan
Tripathi, Manjari; Kaur, Kirandeep; Ramanujam,
OBJECTIVE To determine whether magnetoencepha- Bhargavi; Viswanathan, Vibhin; Bharti, Kamal; Singh,
lography (MEG) can identify epileptiform discharges Gaurav; Singh, Vivek; Garg, Ajay; Bal, Chandra Sekhar;
mimicking small sharp spikes (SSSs) on scalp electro- Tripathi, Madhavi; Sharma, Mehar Chand; Pandey,
encephalography (EEG) in patients with temporal lobe Ravindra; Dash, Deepa; Mandal, Pravat; Chandra,
epilepsy (TLE). Poodipedi Sarat

Neurology, All India Institute of Medical Sciences, New

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