Page 209 - MEGIN Book Of Abstracts - 2023

The value of magnetoencephalography for stereo- follow-up results showed that the probability of being
EEG-guided radiofrequency thermocoagulation in seizure-free at one year after RFTC in MRI-negative
MRI-negative epilepsy (2020) patients with an MEG cluster was 30.0 % (95 % CI 11.6-
77.3 %), significantly (p = 0.014) higher than that in pa-
Gao, Runshi; Yu, Tao; Xu, Cuiping; Zhang, Xiating; Yan, tients without an MEG cluster; there was no significant
Xiaoming; Ni, Duanyu; Zhang, Xiaohua; Ma, Kai; Qiao, difference when compared with MRI-positive patients.
Liang; Zhu, Jin; Wang, Xueyuan; Ren, Zhiwei; Zhang, Xi;
Zhang, Guojun; Li, Yongjie CONCLUSION This is the first study to evaluate the
value of MEG in SEEG-guided RF-TC in MRI-negative
Beijing Institute of Functional Neurosurgery, Xuanwu Hos- epilepsies. MEG is a useful supplement for patients with
pital, Capital Medical University, Beijing, China; Department MRI-negative epilepsy. MEG can be applied in mini-
of Neurology, Xuanwu Hospital, Capital Medical University, mally invasive treatment. MEG clusters can help identify
Beijing, China; Beijing Institute of Functional Neurosurgery, better candidates and provide a valuable target for
Xuanwu Hospital, Capital Medical University, Beijing, China. SEEG-guided RF-TC, which leads to better outcomes.
Electronic address: [email protected]
Epilepsy research (2020), Vol. 163 (32278277) (4 citations)
OBJECTIVE Magnetoencephalography (MEG) is valu-
able for guiding resective surgery in patients with
epilepsy. However, its value for minimally invasive Relative contribution of individual versus combined
treatment is still unknown. This study aims to evalu- functional imaging studies in predicting seizure
ate the value of MEG for stereo-electroencephalogram freedom in pediatric epilepsy surgery: an area
(EEG)-guided radiofrequency thermocoagulation under the curve analysis (2020)
(SEEG-guided RF-TC) in magnetic resonance imaging
(MRI)-negative epilepsies. Kankirawatana, Pongkiat; Mohamed, Ismail S; Lauer,
Jason; Aban, Inmaculada; Kim, Hyunmi; Li, Rong;
METHODS An observational cohort study was per- Harrison, Allan; AS; Goyal, Monisha; Rozzelle, Curtis J;
formed and 19 MRI-negative patients who underwent Knowlton, Robert; Blount, Jeffrey P
SEEG-guided RF-TC in our epilepsy center were includ-
ed. In addition, 16 MRI-positive patients were included Division of Pediatric Neurology, Department of Pediatrics, The
as a reference group. Semiology, electrophysiology, University of Alabama at Birmingham School of Medicine,
and imaging information were collected. To evaluate Birmingham, Alabama; Department of Radiology, Massa-
the value of locating the MEG cluster, the proportion chusetts General Hospital, Boston, Massachusetts; Division
of the RF-TC contacts located in the MEG cluster out of of Biostatistics, UAB School of Public Health, The University of
all contacts used to perform RF-TC in each patient was Alabama at Birmingham, Alabama; Division of Child Neurol-
calculated. All patients underwent the standard SEEG- ogy, Department of Neurology and Neurological Sciences,
guided RF-TC procedure and were followed up after the Stanford University School of Medicine, Palo Alto, California;
treatment. Department of Pathology, The University of Alabama at
Birmingham, Alabama; Division of Pediatric Neurosurgery,
RESULTS Nineteen MRI-negative patients were divided Department of Neurosurgery, The University of Alabama at
into two groups based on the existence of MEG clus- Birmingham School of Medicine, Birmingham, Alabama;
ters; 10 patients with MEG clusters were in group I and and; Department of Neurology, University of California, San
nine patients without any MEG cluster were in group Francisco, California
II. No significant difference was observed in terms of
age, sex, type of seizures, or number of SEEG electrodes OBJECTIVE The goal of this study was to evaluate the
implanted. The median of the proportion of contacts predictive value and relative contribution of noninva-
in the MEG cluster was 77.0 % (IQR 57.7-100.0 %). The sive presurgical functional imaging modalities based

 ontents  Index 188
C