Page 213 - MEGIN Book Of Abstracts - 2023

patients exhibited a widespread RS epileptic network part of clinical epilepsy and tumor presurgical as-
characterized by stronger connectivity between the sessment. Language was mapped in MEG during an
IED generator and the rest of the cortex, in comparison auditory word recognition paradigm, and a laterality
to the contralateral region and the cortex. Differences index was calculated using the number of dipoles and
between the two seizure outcome groups concerned their spatial extent in the two hemispheres. Transcra-
mainly distant long-range connections and were found nial magnetic stimulation language mapping was
in the alpha-band. performed as patients performed a naming task, and
TMS-induced speech disruptions were recorded during
SIGNIFICANCE Importantly, these connectivity pat- 5-Hz TMS applied to anterior and posterior language
terns suggest specific mechanisms describing the cortices. Transcranial magnetic stimulation lateral-
underlying organization of the epileptic network and ity index was estimated using the number and type
were detectable at the individual patient level, support- of speech disruption in the language regions of each
ing the prospect use of MEG connectivity patterns in hemisphere.
epilepsy to predict post-surgical seizure outcome.
RESULTS Transcranial magnetic stimulation and MEG
Journal of neural engineering (2020), Vol. 17, No. 3 estimates of HD were concordant in 42 (63%) patients,
(32191632) (17 citations) resulting in a sensitivity of 74% and a specificity of 72%.
The overall accuracy of TMS was 73%, equivalent to an
odds ratio of 7.35.
The Clinical Utility of Transcranial
Magnetic Stimulation in Determining CONCLUSIONS In this first large-scale comparative
Hemispheric Dominance for Language: A study in a clinical population, we demonstrate that TMS
Magnetoencephalography Comparison Study is a safe and reliable noninvasive tool in determining
(2020) HD for language. Improving the accuracy of TMS by
optimizing TMS parameters and improving task choice
Rezaie, Roozbeh; Schiller, Katherine K; Embury, Luke; will further facilitate the use of TMS to characterize
Boop, Frederick A; Wheless, James W; Narayana, Shalini language function, especially in pediatrics.

Le Bonheur Neuroscience Institute, Le Bonheur Children's Journal of clinical neurophysiology: official publication
Hospital, Memphis, Tennessee, U.S.A; Department of Pediat- of the American Electroencephalographic Society (2020),
rics, University of Tennessee Health Science Center, Memphis, Vol. 37, No. 2 (32142020) (6 citations)
Tennessee, U.S.A; Departments of Neurosurgery and; Neurobi-
ology and Anatomy, University of Tennessee Health Science
Center, Memphis, Tennessee, U.S.A Optically pumped magnetoencephalography in
epilepsy (2020)
PURPOSE Transcranial magnetic stimulation (TMS) has
recently emerged as a noninvasive alternative to the Vivekananda, Umesh; Mellor, Stephanie; Tierney, Tim
intracarotid sodium amytal (Wada) procedure for estab- M; Holmes, Niall; Boto, Elena; Leggett, James; Roberts,
lishing hemispheric dominance (HD) for language. The Gillian; Hill, Ryan M; Litvak, Vladimir; Brookes, Matthew
accuracy of HD determined by TMS was examined by J; Bowtell, Richard; Barnes, Gareth R; Walker, Matthew C
comparing against the HD derived by magnetoenceph-
alography (MEG), a prominent clinical technique with Department of Clinical and Experimental Epilepsy, UCL,
excellent concordance with the Wada procedure. Queen Square Institute of Neurology, London, WC1N 3BG,
United Kingdom; Wellcome Centre for Human Neuroimag-
METHODS Sixty-seven patients (54 patients ≤18 years) ing, UCL, Queen Square, London, WC1N 3AR, United King-
underwent language mapping with TMS and MEG as dom; Sir Peter Mansfield Imaging Centre, School of Physics

 ontents  Index 192
C