Page 214 - MEGIN Book Of Abstracts - 2023

and Astronomy, University of Nottingham, Nottingham, NG7 quency signals that included alpha (α, 8-13 Hz), beta (β,
2RD, United Kingdom 14-30 Hz), and gamma (γ, 31-80 Hz) band oscillations.
Patients with cingulate gyrus epilepsy had significantly
ABSTRACT We demonstrate the first use of Optically greater connectivity in all three frequency bands (α, β,
Pumped Magnetoencephalography (OP-MEG) in an γ). A frequency-specific elevation of functional con-
epilepsy patient with unrestricted head movement. nectivity was found in patients compared to controls.
Current clinical MEG uses a traditional SQUID system, The greater functional connectivity in the γ band was
where sensors are cryogenically cooled and housed in significantly more prominent than that of the α and
a helmet in which the patient's head is fixed. Here, we β bands. Patients with cingulate gyrus epilepsy and
use a different type of sensor (OPM), which operates controls differed significantly in functional connectiv-
at room temperature and can be placed directly on ity between the left angular gyrus and left posterior
the patient's scalp, permitting free head movement. cingulate cortex in the α, β, and γ bands. The results of
We performed OP-MEG recording in a patient with the node degree analysis were similar to those of the
refractory focal epilepsy. OP-MEG-identified analogous functional connectivity analysis. Our findings reveal for
interictal activity to scalp EEG, and source localized this the first time that brain activity in the γ band may play
activity to an appropriate brain region. a key role in the default mode network in cingulate gy-
rus epilepsy. Altered functional connectivity of the left
Annals of clinical and translational neurology (2020), Vol. angular gyrus and left posterior cingulate cortex may
7, No. 3 (32112610) (14 citations) be a new biomarker for cingulate gyrus epilepsy.

Keywords: angular gyrus, cingulate gyrus epilepsy, default
Frequency-specific changes in the default mode mode network, magnetoencephalography
network in patients with cingulate gyrus epilepsy
(2020) Human brain mapping (2020), Vol. 41, No. 9 (32096905) (5
citations)
Leng, Xuerong; Xiang, Jing; Yang, Yingxue; Yu, Tao; Qi,
Xiaohong; Zhang, Xiating; Wu, Siqi; Wang, Yuping
Scalp ripples as prognostic biomarkers of
Department of Pediatrics, Xuanwu Hospital Capital Medical epileptogenicity in pediatric surgery (2020)
University, Beijing, China; MEG Center, Division of Neurology,
Cincinnati Children's Hospital Medical Center, Cincinnati, Tamilia, Eleonora; Dirodi, Matilde; Alhilani, Michel;
Ohio; Center of Epilepsy, Beijing Institute for Brain Disorders, Grant, P Ellen; Madsen, Joseph R; Stufflebeam, Steven
Capital Medical University, Beijing, China; Beijing Institute of M; Pearl, Phillip L; Papadelis, Christos
Functional Neurosurgery, Xuanwu Hospital, Capital Medical
University, Beijing, China Fetal-Neonatal Neuroimaging and Developmental Science
Center, Division of Newborn Medicine, Department of Medi-
ABSTRACT To identify abnormal functional connec- cine, Boston Children's Hospital, Harvard Medical School,
tivity of the default mode network in cingulate gyrus Boston, Massachusetts; G. Tec Medical Engineering GmbH,
epilepsy, which may yield new information about the Guger Technologies OG, Graz, Austria; Division of Epilepsy
default mode network and suggest a new cingulate Surgery, Department of Neurosurgery, Boston Children's
gyrus epilepsy biomarker. Fifteen patients with cin- Hospital, Harvard Medical School, Boston, Massachusetts;
gulate gyrus epilepsy (mean age = 21 years) and 15 Athinoula A. Martinos Center for Biomedical Imaging, Mas-
healthy controls (mean age = 24 years) were studied sachusetts General Hospital, Harvard Medical School, Boston,
in the resting state using magnetoencephalography. Massachusetts; Division of Epilepsy and Clinical Neurophysi-
Twelve brain areas of interest in the default mode ology, Department of Neurology, Boston Children's Hospital,
network were extracted and investigated with multifre- Harvard Medical School, Boston, Massachusetts; Department

 ontents  Index 193
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