Page 221 - MEGIN Book Of Abstracts - 2023

cal evidence from functional activity (as opposed to Altered effective connectivity in migraine patients
anatomical structure) for the differentiation between during emotional stimuli: a multi-frequency
CM and EM, as well as potential functional biomarkers. magnetoencephalography study (2022)
For this purpose, Web of Science (WoS), Scopus, and
PubMed databases were screened. Ren, Jing; Yao, Qun; Tian, Minjie; Li, Feng; Chen, Yueqiu;
Chen, Qiqi; Xiang, Jing; Shi, Jingping
FINDINGS Among the 24 studies included in this re-
view, most of them (22) reported statistically significant Department of Neurology, The Affiliated Brain Hospital of
differences between the groups of CM and EM. This Nanjing Medical University, Nanjing, 210029, Jiangsu, China;
finding is consistent regardless of brain activity acquisi- MEG Center, The Affiliated Brain Hospital of Nanjing Medi-
tion modality, ictal stage, and recording condition for a cal University, Nanjing, 210029, Jiangsu, China; MEG Center,
wide variety of analyses. That speaks for a supramodal Division of Neurology, Cincinnati Children's Hospital Medical
and domain-general differences between CM and EM Center, Cincinnati, OH, 45220, USA; Department of Neurolo-
that goes beyond a differentiation based on the days gy, The Affiliated Brain Hospital of Nanjing Medical University,
of migraine per month. Together, the reviewed studies Nanjing, 210029, Jiangsu, China. [email protected]
demonstrates that electro- and magneto-physiological
brain activity (M/EEG), as well as neurovascular and BACKGROUND Migraine is a common and disabling
metabolic recordings from functional magnetic reso- primary headache, which is associated with a wide
nance imaging (fMRI) and positron emission tomog- range of psychiatric comorbidities. However, the mech-
raphy (PET), show characteristic patterns that allow to anisms of emotion processing in migraine are not fully
differentiate between CM and EM groups. understood yet. The present study aimed to investigate
the neural network during neutral, positive, and nega-
CONCLUSIONS Although a clear brain activity-based tive emotional stimuli in the migraine patients.
biomarker has not yet been identified to distinguish
these subtypes of migraine, research is approaching METHODS A total of 24 migraine patients and 24 age-
headache specialists to a migraine diagnosis based not and sex-matching healthy controls were enrolled in this
only on symptoms and signs reported by patients. Fu- study. Neuromagnetic brain activity was recorded using
ture studies based on M/EEG should pay special atten- a whole-head magnetoencephalography (MEG) system
tion to the brain activity in medium and fast frequency upon exposure to human facial expression stimuli. MEG
bands, mainly the beta band. On the other hand, fMRI data were analyzed in multi-frequency ranges from 1 to
and PET studies should focus on neural circuits and 100 Hz.
regions related to pain and emotional processing.
RESULTS The migraine patients exhibited a signifi-
Keywords: Chronic migraine (CM), Electroencephalog- cant enhancement in the effective connectivity from
raphy (EEG), Episodic migraine (EM), Functional activity, the prefrontal lobe to the temporal cortex during the
Functional magnetic resonance imaging (fMRI), Magneto- negative emotional stimuli in the gamma frequency
encephalography (MEG), Positron emission tomography (30-90 Hz). Graph theory analysis revealed that the mi-
(PET) graine patients had an increased degree and clustering
coefficient of connectivity in the delta frequency range
The journal of headache and pain (2022), Vol. 23, No. 1 (1-4 Hz) upon exposure to positive emotional stimuli
(35927625) (1 citation) and an increased degree of connectivity in the delta
frequency range (1-4 Hz) upon exposure to negative
emotional stimuli. Clinical correlation analysis showed
that the history, attack frequency, duration, and neu-
ropsychological scales of the migraine patients had a

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