Page 25 - MEGIN Book Of Abstracts - 2023

Cortical and subcortical changes in resting- multiple comparisons. BvFTD patients, as compared to
state neuronal activity and connectivity in early ALS and HCs, showed lower relative beta power in pa-
symptomatic ALS and advanced frontotemporal rietal, occipital, temporal and nearly all subcortical re-
dementia (2022) gions. Compared to HCs, patients with ALS and patients
with bvFTD had a higher delta (0.5-4 Hz) and gamma
Govaarts, Rosanne; Beeldman, Emma; Fraschini, (30-48 Hz) band resting-state functional connectivity
Matteo; Griffa, Alessandra; Engels, Marjolein M A; van in a high number of overlapping regions in the fron-
Es, Michael A; Veldink, Jan H; van den Berg, Leonard tal lobe and in limbic and subcortical regions. Higher
H; van der Kooi, Anneke J; Pijnenburg, Yolande A L; de delta band connectivity was widespread in the bvFTD
Visser, Marianne; Stam, Cornelis J; Raaphorst, Joost; patients compared to HCs. ALS showed a more wide-
Hillebrand, Arjan spread higher gamma band functional connectivity
compared to bvFTD. In conclusion, MEG in early symp-
Amsterdam University Medical Centers, University of tomatic ALS patients shows resting-state functional
Amsterdam, Department of Neurology, Amsterdam Neu- connectivity changes in frontal, limbic and subcortical
roscience, Amsterdam, the Netherlands. Electronic address: regions that overlap considerably with bvFTD. The find-
[email protected]; University of Cagliari, ings show the potential of MEG to detect brain changes
Department of Electrical and Electronic Engineering, Cagliari, in early symptomatic phases of ALS and contribute to
Italy; Department of Clinical Neurosciences, Division of Neu- our understanding of the disease spectrum, with ALS
rology, Geneva University Hospitals and Faculty of Medicine, and bvFTD at the two extreme ends.
University of Geneva, Geneva, Switzerland; Institute of Bioen-
gineering, Center of Neuroprosthetics, École Polytechnique Keywords: Amyotrophic lateral sclerosis, Behavioural
Fédérale De Lausanne (EPFL), Geneva, Switzerland; Amster- variant frontotemporal dementia, Functional connectiv-
dam University Medical Centers, Vrije Universiteit Amsterdam, ity, Magnetoencephalography, Oscillatory brain activity,
Department of Clinical Neurophysiology, Magnetoencepha- Resting-state
lography Centre, Amsterdam Neuroscience, Amsterdam, the
Netherlands; University Medical Centre Utrecht, Department NeuroImage. Clinical (2022), Vol. 34 (35217500) (0
of Neurology, Brain Centre Rudolf Magnus, Utrecht, the citations)
Netherlands; Amsterdam University Medical Centers, Vrije
Universiteit, Alzheimer Center, Amsterdam Neuroscience,
Amsterdam, the Netherlands In Amyotrophic Lateral Sclerosis Blood Cytokines
Are Altered, but Do Not Correlate with Changes in
ABSTRACT The objective of this study was to examine Brain Topology (2020)
if patterns of resting-state brain activity and functional
connectivity in cortical and subcortical regions in Polverino, Arianna; Rucco, Rosaria; Stillitano, Ilaria;
patients with early symptomatic amyotrophic lateral Bonavita, Simona; Grimaldi, Manuela; Minino, Roberta;
sclerosis (ALS) resemble those of behavioural variant Pesoli, Matteo; Trojsi, Francesca; D'Ursi, Anna Maria;
frontotemporal dementia (bvFTD). In a cross-sectional Sorrentino, Giuseppe; Sorrentino, Pierpaolo
design, eyes-closed resting-state magnetoencephalog-
raphy (MEG) data of 34 ALS patients, 18 bvFTD patients Institute of Diagnosis and Treatment Hermitage Capodi-
and 18 age- and gender-matched healthy controls monte, Naples, Italy; Institute of Applied Sciences and Intel-
(HCs) were projected to source-space using an atlas- ligent Systems of National Research Council, Pozzuoli, Italy;
based beamformer. Group differences in peak frequen- Department of Pharmacy, University of Salerno, Fisciano,
cy, band-specific oscillatory activity and functional con- Italy; Department of Advanced Medical and Surgical Sci-
nectivity (corrected amplitude envelope correlation) ences, University of Campania "Luigi Vanvitelli," Naples, Italy;
in 78 cortical regions and 12 subcortical regions were Department of Motor and Wellness Sciences, University of
determined. False discovery rate was used to correct for Naples "Parthenope", Naples, Italy; Department of Engineer-

 ontents  Index 4
C