Page 30 - MEGIN Book Of Abstracts - 2023

Memorial Hospital, Hsinchu, Taiwan wan; Healthy Aging Research Center, Chang Gung University,
Taoyuan, Taiwan; Laboratory of Brain Imaging and Neural
ABSTRACT Previous studies have reported that Dynamics (BIND Lab), Chang Gung University, Taoyuan,
patients with panic disorder (PD) exhibited an aber- Taiwan; Department of Psychiatry, Chang Gung Memorial
rant level of GABA concentration, an inhibitory neu- Hospital, Linkou, Taiwan. Electronic address: ch.cheng@mail.
rotransmitter in the human brain. However, it remains cgu.edu.tw; Department of Psychiatry, Chang Gung Memo-
substantially unclear whether the inhibitory function rial Hospital, Linkou, Taiwan; School of Medicine, Chang
regarding the neurophysiological characteristics is Gung University, Taoyuan, Taiwan; Department of Psychiatry,
altered in this disease. Sensory gating (SG) is consid- New Taipei Municipal TuCheng Hospital (Built and Operated
ered as an automatic inhibitory function in the sensory by Chang Gung Medical Foundation), Taiwan
cortex. In addition, brain's gamma oscillation within
the sensory cortex is another index to reflect inhibitory BACKGROUND Mismatch negativity (MMN) or its
function. Here we aimed to investigate whether the magnetic counterpart (MMNm) is a neurophysiological
patients with PD showed altered inhibitory function in signal to reflect the automatic change-detection ability.
the somatosensory system, including the primary (SI) However, MMN studies in patients with panic disorder
and secondary (SII) somatosensory cortices. A total of (PD) showed contrasting results using electroencepha-
20 healthy controls and 21 patients with PD underwent lographic (EEG) recordings. The present study attempt-
magnetoencephalographic recordings. Paired-pulse ed to overcome the limitations of EEG methodology
and single-pulse paradigms were used to study SG and by means of a whole-head magnetoencephalography
gamma oscillations, respectively. There were no signifi- (MEG) combined with the depth-weighted minimum
cant between-group differences in the SG function in norm estimate method to conduct an in-depth inves-
the SI and SII. However, patients with PD demonstrated tigation on the MMNm at the cortical level in patients
a reduced gamma power in the SI. Among the healthy with PD.
individuals, strong associations between SG ratios and
gamma frequency values were observed in the SI. How- METHODS We recruited 22 healthy controls (HC)
ever, such a functional relationship disappeared among and 20 patients with PD to perform auditory oddball
the patients with PD. We suggested the reduced cou- paradigm during MEG recordings. The cortical MMNm
pling of SG and gamma oscillation as one of the neural amplitudes and latencies in the superior temporal
signatures in PD. gyrus, inferior parietal lobule, and inferior frontal gyrus
(IFG) were compared between the HC and PD groups.
Keywords: Gamma oscillation, Inhibitory function, Magne- The correlations between MMNm responses and clini-
toencephalography (MEG), Primary somatosensory cortex cal measurement were also examined.
(SI), Sensory gating
RESULTS Compared with the HC group, the PD group
Psychiatry research. Neuroimaging (2021), Vol. 307 demonstrated significantly reduced MMNm amplitudes
(33248324) (0 citations) in the IFG. Furthermore, higher trait scores of the State-
Trait Anxiety Inventory were associated with lower
MMNm amplitudes of the right IFG among patients
Dysfunctional frontal activation of with PD.
mismatch negativity in panic disorder: A
magnetoencephalographic study (2021) LIMITATIONS Generalization of the current results to
other settings or samples should be made cautiously
Cheng, Chia-Hsiung; Hsu, Shih-Chieh; Liu, Chia-Yih due to the use of different medication regimens and
presence of comorbidities in our patients.
Department of Occupational Therapy and Graduate Institute
of Behavioral Sciences, Chang Gung University, Taoyuan, Tai-

 ontents  Index 9
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