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Attention-Deficit Hyperactivity Disorder
Electrophysiological Brain Changes Associated With information on clinical symptoms was collected from
Cognitive Improvement in a Pediatric Attention the child´s legal guardians.
Deficit Hyperactivity Disorder Digital Artificial
Intelligence-Driven Intervention: Randomized RESULTS In line with our main hypothesis, we found
Controlled Trial (2021) evidence that smart, digital, cognitive treatment results
in improvements in inhibitory control performance.
Medina, Rafael; Bouhaben, Jaime; de Ramón, Ignacio; Improvements were also found in visuospatial work-
Cuesta, Pablo; Antón-Toro, Luis; Pacios, Javier; Quintero, ing memory performance and in the cognitive flex-
Javier; Ramos-Quiroga, Josep Antoni; Maestú, Fernando ibility, working memory, and behavior and general
executive functioning behavioral clinical indexes in
Sincrolab Ltd, Madrid, Spain; Faculty of Health, Camilo Jose this group of participants. Finally, the improvements
Cela University, Villafranca del Castillo, Spain; Radiology found in inhibitory control were related to increases in
Rehabilitation and Physiotherapy, Complutense University of alpha-band power in all participants in the posterior
Madrid, Madrid, Spain; Department of Experimental Psychol- regions, including 2 default mode network regions of
ogy, Faculty of Psychology, Complutense University of Madrid, the interest: the bilateral precuneus and the bilateral
Madrid, Spain; Department of Psychiatry, University Hospital posterior cingulate cortex. However, only the partici-
Infanta Leonor, Madrid, Spain; Biomedical Network Research pants who underwent cognitive stimulation interven-
Centre on Mental Health, Barcelona, Spain tion (KAD_SCL_01) showed a significant increase in this
relationship.
BACKGROUND Cognitive stimulation therapy appears
to show promising results in the rehabilitation of im- CONCLUSIONS The results seem to indicate that smart,
paired cognitive processes in attention deficit hyperac- digital treatment can be effective in the inhibitory con-
tivity disorder. trol and visuospatial working memory rehabilitation in
patients with attention deficit hyperactivity disorder.
OBJECTIVE Encouraged by this evidence and the ever- Furthermore, the relation of the inhibitory control with
increasing use of technology and artificial intelligence alpha-band power changes could mean that these
for therapeutic purposes, we examined whether cogni- changes are a product of plasticity mechanisms or
tive stimulation therapy implemented on a mobile de- changes in the neuromodulatory dynamics.
vice and controlled by an artificial intelligence engine
can be effective in the neurocognitive rehabilitation of TRIAL REGISTRATION ISRCTN Registry IS-
these patients. RCTN71041318; https://www.isrctn.com/IS-
RCTN71041318.
METHODS In this randomized study, 29 child partici-
pants (25 males) underwent training with a smart, Keywords: ADHD, AI, Conners continuous performance
digital, cognitive stimulation program (KAD_SCL_01) test, KAD_SCL_01, artificial intelligence, attention deficit
or with 3 commercial video games for 12 weeks, 3 days hyperactivity disorder, children, cognitive impairment,
a week, 15 minutes a day. Participants completed a
neuropsychological assessment and a preintervention
and postintervention magnetoencephalography study
in a resting state with their eyes closed. In addition,
ontents Index 11
C