Page 27 - MEGIN Book Of Abstracts - 2023

Anxiety Disorders

Preliminary Observations of Resting-State optimal to study neural correlates of illness and identify
Magnetoencephalography in Nonmedicated brain-based markers, given the proximity to illness
Children with Obsessive-Compulsive Disorder onset. Methods: Magnetoencephalography (MEG) data
(2022) were analyzed at rest, in 18 medication-naive children
with OCD (M = 12.1 years ±2.0 standard deviation [SD];
Tan, Vinh; Dockstader, Colleen; Moxon-Emre, Iska; 10 M/8 F) and 13 typically developing children (M = 12.3
Mendlowitz, Sandra; Schacter, Reva; Colasanto, years ±2.2 SD; 6 M/7 F). Whole-brain MEG-derived
Marlena; Voineskos, Aristotle N; Akingbade, Aquila; resting-state functional connectivity (rs-fc), for alpha-
Nishat, Eman; Mabbott, Donald J; Arnold, Paul D; Ameis, and gamma-band frequencies were compared be-
Stephanie H tween OCD and typically developing (control) groups.
Results: Increased MEG-derived rs-fc across alpha- and
Kimel Family Translational Imaging Genetics Research gamma-band frequencies was found in the OCD group
Laboratory, Centre for Addiction and Mental Health, Toronto, compared to the control group. Increased MEG-derived
Canada; Human Biology Program, Faculty of Arts and Sci- rs-fc at alpha-band frequencies was evident across
ence, University of Toronto, Toronto, Canada; Cundill Centre a number of regions within the CSTC circuitry and
for Child and Youth Depression, Margaret and Wallace beyond, including the cerebellum and limbic regions.
McCain Centre for Child, Youth and Family Mental Health, Increased MEG-derived rs-fc at gamma-band frequen-
Campbell Family Mental Health Research Institute, Centre cies was restricted to the frontal and temporal cortices.
for Addiction and Mental Health, Toronto, Canada; Depart- Conclusions: This MEG study provides preliminary
ment of Psychiatry, Temerty Faculty of Medicine, University evidence of altered alpha and gamma networks, at rest,
of Toronto, Toronto, Canada; Department of Psychiatry, The in medication-naive children with OCD. These results
Hospital for Sick Children, Toronto, Canada; Department of support prior findings pointing to the relevance of
Applied Psychology and Human Development, Ontario Insti- CSTC circuitry in pediatric OCD and further support ac-
tute for Studies in Education, University of Toronto, Toronto, cumulating evidence of altered connectivity between
Canada; Department of Physiology, Temetry Faculty of Medi- regions that extend beyond this network, including the
cine, University of Toronto, Toronto, ON, Canada; Depart- cerebellum and limbic regions. Given the substantial
ment of Psychology, University of Toronto, Toronto, Canada; portion of children and youth whose OCD symptoms
Department of Psychiatry, Cumming School of Medicine, do not respond to conventional treatments, our find-
The Mathison Centre for Mental Health Research & Educa- ings have implications for future treatment innovation
tion, Hotchkiss Brain Institute, University of Calgary, Calgary, research aiming to target and track whether brain
Canada; Neuroscience and Mental Health, The Hospital for patterns associated with having OCD may change with
Sick Children, Toronto, Canada treatment and/or predict treatment response.

ABSTRACT Background: Cortico-striato-thalamo- Keywords: MEG, OCD, brain oscillations, frequency bands,
cortical (CSTC) network alterations are hypothesized magnetoencephalography, medication naive, obsessive-
to contribute to symptoms of obsessive-compulsive compulsive disorder, pediatric, resting-state functional
disorder (OCD). To date, very few studies have ex- connectivity, rs-fc
amined whether CSTC network alterations are pres-
ent in children with OCD, who are medication naive. Journal of child and adolescent psychopharmacology
Medication-naive pediatric imaging samples may be (2022), Vol. 32, No. 10 (36548364) (0 citations)

 ontents  Index 6
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