Page 34 - MEGIN Book Of Abstracts - 2023

ment of Diagnostic Imaging, Hospital for Sick Children, 555 yet been validated for use in magnetoencephalography
University Ave, Toronto, ON M5G 1X8, Canada; Program in (MEG), and it has yet to be shown whether its effects
Neurosciences and Mental Health, Hospital for Sick Children, are stable in clinical populations. Across typically devel-
Toronto, Canada; Department of Medical Imaging, University oping (N = 32) children and adolescents and those with
of Toronto, Toronto, Canada; Program in Neurosciences and ASD (N = 46) and ADHD (N = 42), we demonstrate that
Mental Health, Hospital for Sick Children, Toronto, Canada; head motion is reduced during Inscapes. Due to the
Department of Medical Biophysics, University of Toronto, task state evoked by movie paradigms, we also expect-
Toronto, Canada; Wellcome Centre for Integrative Neuroim- edly observed concomitant modulations in local neural
aging, FMRIB, Nuffield Department of Clinical Neurosciences, activity (oscillatory power) and functional connectivity
University of Oxford, Oxford, United Kingdom; Department of (phase and envelope coupling) in intrinsic resting-state
Diagnostic Imaging, Hospital for Sick Children, 555 University networks and across the frequency spectra compared
Ave, Toronto, ON M5G 1X8, Canada; Program in Neurosci- to a fixation cross resting-state. Increases in local activ-
ences and Mental Health, Hospital for Sick Children, Toronto, ity were accompanied by decreases in low-frequency
Canada; Department of Medical Imaging, University of connectivity within and between resting-state net-
Toronto, Toronto, Canada; Department of Psychology, Uni- works, primarily the visual network, suggesting that
versity of Toronto, Toronto, Canada task-state evoked by Inscapes moderates ongoing and
spontaneous cortical inhibition that forms the idling
ABSTRACT Examining the brain at rest is a powerful intrinsic networks found during a fixation cross resting-
approach used to understand the intrinsic properties of state. Importantly, these effects were similar in ASD and
typical and disordered human brain function, yet task- ADHD, making Inscapes a well-suited advancement for
free paradigms are associated with greater head mo- investigations of resting brain function in young and
tion, particularly in young and/or clinical populations clinical populations.
such as autism spectrum disorder (ASD) and attention-
deficit/hyperactivity disorder (ADHD). Inscapes, a Keywords: Attention-deficit/hyperactivity disorder, Autism
non-social and non-verbal movie paradigm, has been spectrum disorder, Inscapes, Magnetoencephalography,
introduced to increase attention, thus mitigating head Neurodevelopmental disorders, Resting-state
motion, while reducing the task-induced activations
found during typical movie watching. Inscapes has not NeuroImage (2021), Vol. 225 (33147510) (4 citations)

 ontents  Index 13
C