Page 39 - MEGIN Book Of Abstracts - 2023

toencephalography, we measured cortical responses School of Medicine, Osaka, Japan; Department of Pediatrics,
to unattended (passively experienced) auditory Osaka University Graduate School of Medicine, Osaka, Japan.
stimuli while parametrically manipulating the degree Electronic address: [email protected]; Division of
of temporal coherence that facilitates auditory figure- Developmental Neuroscience, Department of Child Develop-
ground segregation. Results from 21 children with ASD ment, United Graduate School of Child Development, Osaka
(aged 7-17 years) and 26 age- and IQ-matched typically University, Osaka, Japan; Department of Pediatrics, Osaka
developing children provide evidence that children University Graduate School of Medicine, Osaka, Japan; Inter-
with ASD show anomalous growth of cortical neural national Research Center for Neurointelligence, The Univer-
responses with increasing temporal coherence of the sity of Tokyo, Tokyo, Japan
auditory figure. The documented neurophysiologi-
cal abnormalities did not depend on age, and were BACKGROUND Atypical sensory behavior disrupts
reflected both in the response evoked by changes in behavioral adaptation in children with autism spectrum
temporal coherence of the auditory scene and in the disorder (ASD); however, neural correlates of sensory
associated induced gamma rhythms. Furthermore, the dysfunction using magnetoencephalography (MEG)
individual neural measures were predictive of diagno- remain unclear.
sis (83% accuracy) and also correlated with behavioral
measures of ASD severity and auditory processing METHOD We used MEG to measure the cortical activa-
abnormalities. These findings offer new insight into the tion elicited by visual (uni)/audiovisual (multisensory)
neural mechanisms underlying auditory perceptual movies in 46 children (7-14 years) were included in final
deficits and sensory overload in ASD, and suggest that analysis: 13 boys with atypical audiovisual behavior in
temporal-coherence-based auditory scene analysis and ASD (AAV+), 10 without this condition, and 23 age-
suprathreshold processing of coherent auditory objects matched typically developing boys.
may be atypical in ASD.
RESULTS The AAV+ group demonstrated an increase in
PLoS biology (2022), Vol. 20, No. 2 (35167585) (1 citation) the cortical activation in the bilateral insula in response
to unisensory movies and in the left occipital, right su-
perior temporal sulcus (rSTS), and temporal regions to
Abnormal cortical responses elicited by audiovisual multisensory movies. These increased responses were
movies in patients with autism spectrum correlated with severity of the sensory impairment.
disorder with atypical sensory behavior: A Increased theta-low gamma oscillations were observed
magnetoencephalographic study (2022) in the rSTS in AAV+.

Matsuzaki, Junko; Kagitani-Shimono, Kuriko; Aoki, Sho; CONCLUSION The findings suggest that AAV is attrib-
Hanaie, Ryuzo; Kato, Yoko; Nakanishi, Mariko; Tatsumi, uted to atypical neural networks centered on the rSTS.
Aika; Tominaga, Koji; Yamamoto, Tomoka; Nagai, Yukie;
Mohri, Ikuko; Taniike, Masako Keywords: Atypical audiovisual behavior, Audiovisual
movies, Autism spectrum disorders, Magnetoencephalog-
Division of Developmental Neuroscience, Department of raphy, Sensory processing
Child Development, United Graduate School of Child Devel-
opment, Osaka University, Osaka, Japan; Molecular Research Brain & development (2022), Vol. 44, No. 2 (34563417) (0
Center for Children's Mental Development, Osaka University citations)
Graduate School of Medicine, Osaka, Japan; Division of
Developmental Neuroscience, Department of Child Develop-
ment, United Graduate School of Child Development, Osaka
University, Osaka, Japan; Molecular Research Center for
Children's Mental Development, Osaka University Graduate

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