Page 42 - MEGIN Book Of Abstracts - 2023

McGuiggan, Nicole M; Joseph, Robert M; Hämäläinen, temporal and parietal language regions where TD
Matti S; Kenet, Tal individuals exhibited stronger responses to meaningful
speech. Maturational trajectories of meaningful speech
Department of Neurology, Massachusetts General Hospital, responses were atypical in temporal, but not parietal,
Harvard Medical School, Boston, MA, USA; Athinoula A. regions in ASD. Temporal responses were associated
Martinos Center for Biomedical Imaging, Massachusetts with ASD severity, while parietal responses were associ-
General Hospital, Harvard Medical School, Boston, MA, USA. ated with aberrant involuntary attentional shifting in
Electronic address: [email protected]; Department of ASD. Our findings suggest a receptive speech process-
Neurology, Massachusetts General Hospital, Harvard Medical ing dysfunction in ASD, wherein unattended meaning-
School, Boston, MA, USA; Department of Speech, Language, ful speech elicits abnormal engagement of the lan-
and Hearing Sciences, and Weldon School of Biomedical En- guage system, while unattended meaningless speech,
gineering, Purdue University, West Lafayette, IN, USA; Depart- filtered out in TD individuals, engages the language
ment of Neurology, Massachusetts General Hospital, Harvard system through involuntary attention capture.
Medical School, Boston, MA, USA; Department of Radiology,
Massachusetts General Hospital, Harvard Medical School, Keywords: Auditory, Autism, Event-related fields, Lan-
Boston, MA, USA; Athinoula A. Martinos Center for Bio- guage, Magnetoencephalography, Speech
medical Imaging, Massachusetts General Hospital, Harvard
Medical School, Boston, MA, USA; Department of Speech, Progress in neurobiology (2021), Vol. 203 (34033856) (1
Language, and Hearing Sciences, Boston University, Boston, citation)
MA, USA; Department of Neurology, Massachusetts General
Hospital, Harvard Medical School, Boston, MA, USA; Gradu-
ate School of Education, University of California, Riverside, Shorter P1m Response in Children with Autism
CA, USA; Department of Anatomy and Neurobiology, Boston Spectrum Disorder without Intellectual Disabilities
University School of Medicine, Boston, MA, USA; Department (2021)
of Neurology, Massachusetts General Hospital, Harvard Medi-
cal School, Boston, MA, USA; Athinoula A. Martinos Center Yoshimura, Yuko; Ikeda, Takashi; Hasegawa, Chiaki;
for Biomedical Imaging, Massachusetts General Hospital, An, Kyung-Min; Tanaka, Sanae; Yaoi, Ken; Iwasaki,
Harvard Medical School, Boston, MA, USA. Electronic address: Sumie; Saito, Daisuke N; Kumazaki, Hirokazu; Hiraishi,
[email protected] Hirotoshi; Kikuchi, Mitsuru

ABSTRACT Autism spectrum disorder (ASD) is associ- Higher Brain Function & Autism Research, United Gradu-
ated with widespread receptive language impairments, ate School of Child Development, Kanazawa University,
yet the neural mechanisms underlying these deficits Kanazawa 920-8640, Japan; Research Center for Child
are poorly understood. Neuroimaging has shown Mental Development, Kanazawa University, Kanazawa 920-
that processing of socially-relevant sounds, including 8640, Japan; Human Communication Science & Intervention,
speech and non-speech, is atypical in ASD. However, it United Graduate School of Child Development, Kanazawa
is unclear how the presence of lexical-semantic mean- University, Kanazawa 920-8640, Japan; Faculty of Psychol-
ing affects speech processing in ASD. Here, we recorded ogy, Yasuda Women's University, Hiroshima 731-0153, Japan;
magnetoencephalography data from individuals with Department of Preventive Intervention for Psychiatric Dis-
ASD (N = 22, ages 7-17, 4 females) and typically devel- orders, National Center of Neurology and Psychiatry, Tokyo
oping (TD) peers (N = 30, ages 7-17, 5 females) during 187-8553, Japan; Department of Biofunctional Imaging,
unattended listening to meaningful auditory speech Hamamatsu University School of Medicine, Hamamatsu 431-
sentences and meaningless jabberwocky sentences. 3192, Japan; Department of Psychiatry and Neurobiology,
After adjusting for age, ASD individuals showed stron- Graduate School of Medical Science, Kanazawa University,
ger responses to meaningless jabberwocky sentences Kanazawa 920-8641, Japan
than to meaningful speech sentences in the same left

 ontents  Index 21
C