Page 41 - MEGIN Book Of Abstracts - 2023

ABSTRACT Impairments in social functioning are hall- and Education, Moscow, Russian Federation; MedTech West
marks of autism spectrum disorder (ASD) and atypical and the Institute of Neuroscience and Physiology, Sahlgren-
functional connectivity may underlie these difficul- ska Academy, The University of Gothenburg, Gothenburg,
ties. Emotion processing networks typically undergo Sweden; MedTech West and the Institute of Neuroscience and
protracted maturational changes, however, those with Physiology, Sahlgrenska Academy, The University of Gothen-
ASD show either hyper- or hypo-connectivity with little burg, Gothenburg, Sweden. [email protected]
consensus on the functional connectivity underpinning
emotion processing. Magnetoencephalography was ABSTRACT Gamma oscillations are driven by local
used to investigate age-related changes in whole-brain cortical excitatory (E)-inhibitory (I) loops and may help
functional connectivity of eight regions of interest dur- to characterize neural processing involving excitatory-
ing happy and angry face processing in 190 children, inhibitory interactions. In the visual cortex reliable
adolescents and adults (6-39 years) with and without gamma oscillations can be recorded with magneto-
ASD. Findings revealed age-related changes from child- encephalography (MEG) in the majority of individuals,
through to mid-adulthood in functional connectivity which makes visual gamma an attractive candidate
in controls and in ASD in theta, as well as age-related for biomarkers of brain disorders associated with E/I
between-group differences across emotions, with con- imbalance. Little is known, however, about if/how these
nectivity decreasing in ASD, but increasing for controls, oscillations reflect individual differences in neural excit-
in gamma. Greater connectivity to angry faces was ability and associated sensory/perceptual phenomena.
observed across groups in gamma. Emotion-specific The power of visual gamma response (GR) changes
age-related between-group differences in beta were nonlinearly with increasing stimulation intensity: it
also found, that showed opposite trends with age for increases with transition from static to slowly drift-
happy and angry in ASD. Our results establish altered, ing high-contrast grating and then attenuates with
frequency-specific developmental trajectories of func- further increase in the drift rate. In a recent MEG study
tional connectivity in ASD, across distributed networks we found that the GR attenuation predicted sensitiv-
and a broad age range, which may finally help explain ity to sensory stimuli in everyday life in neurotypical
the heterogeneity in the literature. adult men and in men with autism spectrum disorders.
Here, we replicated these results in neurotypical female
Keywords: ASD, Age-related changes, Development, Emo- participants. The GR enhancement with transition from
tional face processing, Functional connectivity, Magneto- static to slowly drifting grating did not correlate sig-
encephalography nificantly with the sensory sensitivity measures. These
findings suggest that weak velocity-related attenua-
Developmental cognitive neuroscience (2021), Vol. 51 tion of the GR is a reliable neural concomitant of visual
(34416703) (0 citations) hypersensitivity and that the degree of GR attenuation
may provide useful information about E/I balance in
the visual cortex.
Visual gamma oscillations predict sensory
sensitivity in females as they do in males (2021) Scientific reports (2021), Vol. 11, No. 1 (34103578) (0
citations)
Manyukhina, Viktoriya O; Rostovtseva, Ekaterina
N; Prokofyev, Andrey O; Obukhova, Tatiana S;
Schneiderman, Justin F; Stroganova, Tatiana A; Altered maturation and atypical cortical processing
Orekhova, Elena V of spoken sentences in autism spectrum disorder
(2021)
National Research University Higher School of Economics,
Moscow, Russian Federation; Center for Neurocognitive Re- Alho, Jussi; Bharadwaj, Hari; Khan, Sheraz; Mamashli,
search (MEG Center), Moscow State University of Psychology Fahimeh; Perrachione, Tyler K; Losh, Ainsley;

 ontents  Index 20
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