Page 37 - MEGIN Book Of Abstracts - 2023

abilities measured directly in formal assessment. In in autistic individuals. Twenty-five autistic adolescents
the present study, we used MEG and individual brain participated in this randomized, double-blind MEG
models to investigate 40 Hz ASSR in primary-school- study. Autistic individuals arrived at the lab twice and
aged children with and without ASD. It was also used received an acute dose of intranasal OT or placebo in
to assess how the strength of the auditory response each session. During the scans, participants were asked
is related to language abilities of children with ASD, to identify pictures of social and non-social stimuli.
their non-verbal IQ, and social functioning. A total of 40 Additionally, 23 typically developing (TD) adolescents
children were included in the study. The results demon- performed the same task in the MEG as a benchmark
strated that 40 Hz ASSR was reduced in the right audi- that allowed us to better characterize neural regions
tory cortex in children with ASD when comparing them of interest and behavioral results for this age group in
to typically developing controls. Importantly, our study this task. A source-model beamformer analysis revealed
provides the first evidence of the association between that OT enhanced neural activity for social stimuli in
40 Hz ASSR in the language-dominant left auditory frontal regions during M170. Additionally, in each of
cortex and language comprehension in children with the preselected time windows, OT increased activa-
ASD. This link was domain-specific because the other tion in the left hemisphere, regardless of the content
brain-behavior correlations were non-significant. of the presented stimuli. We suggest that OT increased
the processing of social stimuli through two separate
Keywords: 40Hz Auditory Steady-State Response (40Hz mechanisms. First, OT increased neural activity in a
ASSR), Amplitude-modulated tones, Auditory gamma nonspecific manner, allowing increased allocation of
oscillations, Autism Spectrum Disorder (ASD), Magnetoen- attention toward the stimuli. Second, OT enhanced
cephalography (MEG) M170 activity in frontal regions only in response to
social stimuli. These results reveal the temporal dynam-
Progress in neuro-psychopharmacology & biological ics of the effects of OT on the early stages of social and
psychiatry (2023), Vol. 122 (36470421) (0 citations) non-social perception in autistic adolescents.Trial reg-
istration: This study was a part of a project registered
as clinical trial October 27th, 2021. ClinicalTrials.gov
The dual neural effects of oxytocin in autistic youth: Identifier: NCT05096676.
results from a randomized trial (2022)
Scientific reports (2022), Vol. 12, No. 1 (36175473) (0
Korisky, Adi; Goldstein, Abraham; Gordon, Ilanit citations)

The Gonda Multidisciplinary Brain Research Center, Bar-
Ilan University, 5290002, Ramat Gan, Israel; Department of Globally elevated excitation-inhibition ratio in
Psychology, Bar-Ilan University, 5290002, Ramat Gan, Israel; children with autism spectrum disorder and below-
Department of Psychology, Bar-Ilan University, 5290002, average intelligence (2022)
Ramat Gan, Israel. [email protected]
Manyukhina, Viktoriya O; Prokofyev, Andrey O; Galuta,
ABSTRACT Recent discoveries have highlighted the Ilia A; Goiaeva, Dzerassa E; Obukhova, Tatiana S;
effects of oxytocin (OT) on social behavior and per- Schneiderman, Justin F; Altukhov, Dmitrii I; Stroganova,
ception among autistic individuals. However, a gap Tatiana A; Orekhova, Elena V
persists in the literature regarding the potential effects
of OT and the neural temporal dynamics due to OT Department of Psychology, National Research University
administration. We explored the effect of OT on autistic Higher School of Economics, Moscow, Russian Federation;
individuals using magnetoencephalography (MEG), fo- Center for Neurocognitive Research (MEG Center), Moscow
cusing on M100, M170, and M250, social perception-re- State University of Psychology and Education, Moscow, Rus-
lated components that tend to show atypical patterns sian Federation; MedTech West and the Institute of Neurosci-

 ontents  Index 16
C