Page 45 - MEGIN Book Of Abstracts - 2023

studies show cerebellar abnormalities in ASD. Here, we cine, Chiba University and University of Fukui, Kanazawa,
elucidate the spatiotemporal activation of cerebellar Japan. Electronic address: [email protected];
lobules in ASD during emotional processing of happy Research Center for Child Mental Development, Kanazawa
and angry faces in adolescents with ASD and typically University, Kanazawa, Japan; Division of Socio-Cognitive-
developing (TD) controls. Using magnetoencephalog- Neuroscience, Department of Child Development United
raphy, we calculated dynamic statistical parametric Graduate School of Child Development, Osaka University,
maps across a period of 500 ms after emotional stimuli Kanazawa University, Hamamatsu University School of Medi-
onset and determined differences between group cine, Chiba University and University of Fukui, Kanazawa,
activity to happy and angry emotions. Following happy Japan; Institute of Human and Social Sciences, Kanazawa
face presentation, adolescents with ASD exhibited University, Kanazawa, Japan; Centre for Human Brain Health,
only left-hemispheric cerebellar activation in a cluster School of Psychology, University of Birmingham, United
extending from lobule VI to lobule V (compared to TD Kingdom; Research Center for Child Mental Development,
controls). Following angry face presentation, ado- Kanazawa University, Kanazawa, Japan; Division of Socio-
lescents with ASD exhibited only midline cerebellar Cognitive-Neuroscience, Department of Child Development
activation (posterior IX vermis). Our findings indicate an United Graduate School of Child Development, Osaka
early (125-175 ms) overactivation in cerebellar activ- University, Kanazawa University, Hamamatsu University
ity only for happy faces and a later overactivation for School of Medicine, Chiba University and University of Fukui,
both happy (250-450 ms) and angry (250-350 ms) faces Kanazawa, Japan; Department of Psychiatry and Behavioral
in adolescents with ASD. The prioritized hemispheric Science, Kanazawa University, Kanazawa, Japan. Electronic
activity (happy faces) could reflect the promotion of a address: [email protected]
more flexible and adaptive social behavior, while the
latter midline activity (angry faces) may guide conform- ABSTRACT Autism spectrum disorder (ASD) often in-
ing behavior. volves dysfunction in general motor control and motor
coordination, in addition to core symptoms. However,
Keywords: adolescence, autism spectrum disorder, cer- the neural mechanisms underlying motor dysfunction
ebellum, emotions, face processing, magnetoencepha- in ASD are poorly understood. To elucidate this issue,
lography we focused on brain oscillations and their coupling in
the primary motor cortex (M1). We recorded magne-
Human brain mapping (2021), Vol. 42, No. 7 (33528852) (0 toencephalography in 18 children with ASD, aged 5 to
citations) 7 years, and 19 age- and IQ-matched typically-devel-
oping children while they pressed a button during a
video-game-like motor task. The motor-related gamma
Aberrant brain oscillatory coupling from the (70 to 90 Hz) and pre-movement beta oscillations (15 to
primary motor cortex in children with autism 25 Hz) were analyzed in the primary motor cortex using
spectrum disorders (2021) an inverse method. To determine the coupling between
beta and gamma oscillations, we applied phase-ampli-
An, Kyung-Min; Ikeda, Takashi; Hasegawa, Chiaki; tude coupling to calculate the statistical dependence
Yoshimura, Yuko; Tanaka, Sanae; Saito, Daisuke N; between the amplitude of fast oscillations and the
Yaoi, Ken; Iwasaki, Sumie; Hirosawa, Tetsu; Jensen, Ole; phase of slow oscillations. We observed a motor-related
Kikuchi, Mitsuru gamma increase and a pre-movement beta decrease
in both groups. The ASD group exhibited a reduced
Research Center for Child Mental Development, Kanazawa motor-related gamma increase and enhanced pre-
University, Kanazawa, Japan; Division of Socio-Cognitive- movement beta decrease in the ipsilateral primary
Neuroscience, Department of Child Development United motor cortex. We found phase-amplitude coupling, in
Graduate School of Child Development, Osaka University, which high-gamma activity was modulated by the beta
Kanazawa University, Hamamatsu University School of Medi- rhythm in the primary motor cortex. Phase-amplitude

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