Page 49 - MEGIN Book Of Abstracts - 2023

Children with ASD did not show this pattern of learning free paradigms are associated with greater head mo-
in all three regions. We discuss two possible hypotheses tion, particularly in young and/or clinical populations
related to children's sensitivity to bottom-up sensory such as autism spectrum disorder (ASD) and attention-
deficits and difficulty with top-down incremental pro- deficit/hyperactivity disorder (ADHD). Inscapes, a
cessing. non-social and non-verbal movie paradigm, has been
introduced to increase attention, thus mitigating head
Keywords: ASD, MEG, development, language, statistical motion, while reducing the task-induced activations
learning found during typical movie watching. Inscapes has not
yet been validated for use in magnetoencephalography
eNeuro (2020), Vol. 7, No. 6 (33199412) (0 citations) (MEG), and it has yet to be shown whether its effects
are stable in clinical populations. Across typically devel-
oping (N = 32) children and adolescents and those with
Characterizing Inscapes and resting-state in MEG: ASD (N = 46) and ADHD (N = 42), we demonstrate that
Effects in typical and atypical development (2021) head motion is reduced during Inscapes. Due to the
task state evoked by movie paradigms, we also expect-
Vandewouw, Marlee M; Dunkley, Benjamin T; Lerch, edly observed concomitant modulations in local neural
Jason P; Anagnostou, Evdokia; Taylor, Margot J activity (oscillatory power) and functional connectivity
(phase and envelope coupling) in intrinsic resting-state
Department of Diagnostic Imaging, Hospital for Sick networks and across the frequency spectra compared
Children, 555 University Ave, Toronto, ON M5G 1X8, Canada; to a fixation cross resting-state. Increases in local activ-
Program in Neurosciences and Mental Health, Hospital for ity were accompanied by decreases in low-frequency
Sick Children, Toronto, Canada; Autism Research Centre, connectivity within and between resting-state net-
Bloorview Research Institute, Holland Bloorview Kids Reha- works, primarily the visual network, suggesting that
bilitation Hospital, Toronto, ON, Canada; Institute of Biomedi- task-state evoked by Inscapes moderates ongoing and
cal Engineering, University of Toronto, Toronto, Canada. spontaneous cortical inhibition that forms the idling
Electronic address: [email protected]; Depart- intrinsic networks found during a fixation cross resting-
ment of Diagnostic Imaging, Hospital for Sick Children, 555 state. Importantly, these effects were similar in ASD and
University Ave, Toronto, ON M5G 1X8, Canada; Program in ADHD, making Inscapes a well-suited advancement for
Neurosciences and Mental Health, Hospital for Sick Children, investigations of resting brain function in young and
Toronto, Canada; Department of Medical Imaging, University clinical populations.
of Toronto, Toronto, Canada; Program in Neurosciences and
Mental Health, Hospital for Sick Children, Toronto, Canada; Keywords: Attention-deficit/hyperactivity disorder, Autism
Department of Medical Biophysics, University of Toronto, spectrum disorder, Inscapes, Magnetoencephalography,
Toronto, Canada; Wellcome Centre for Integrative Neuroim- Neurodevelopmental disorders, Resting-state
aging, FMRIB, Nuffield Department of Clinical Neurosciences,
University of Oxford, Oxford, United Kingdom; Department of NeuroImage (2021), Vol. 225 (33147510) (4 citations)
Diagnostic Imaging, Hospital for Sick Children, 555 University
Ave, Toronto, ON M5G 1X8, Canada; Program in Neurosci-
ences and Mental Health, Hospital for Sick Children, Toronto, MEG Theta during Lexico-Semantic and Executive
Canada; Department of Medical Imaging, University of Processing Is Altered in High-Functioning
Toronto, Toronto, Canada; Department of Psychology, Uni- Adolescents with Autism (2021)
versity of Toronto, Toronto, Canada
You, Yuqi; Correas, Angeles; Jao Keehn, R Joanne;
ABSTRACT Examining the brain at rest is a powerful Wagner, Laura C; Rosen, Burke Q; Beaton, Lauren E;
approach used to understand the intrinsic properties of Gao, Yangfeifei; Brocklehurst, William T; Fishman, Inna;
typical and disordered human brain function, yet task- Müller, Ralph-Axel; Marinkovic, Ksenija

 ontents  Index 28
C