Page 54 - MEGIN Book Of Abstracts - 2023

vention Center of Excellence, University Hospital Frankfurt, Keywords: ASD, Beta-band oscillations, MEG, Motor re-
Goethe University, Frankfurt am Main, Germany. moliadze@ sponse inhibition
med-psych.uni-kiel.de; MEG Unit, Brain Imaging Center,
University Hospital Frankfurt, Goethe University, Frankfurt Brain topography (2020), Vol. 33, No. 3 (32303950) (2
am Main, Germany; Department of Child and Adolescent citations)
Psychiatry and Psychotherapy, Ev. Hospital Bethel, Bielefeld,
Germany; Institute of Mathematical Problems of Biology
RAS - the Branch of Keldysh Institute of Applied Mathematics Auditory steady-state response at 20 Hz and 40 Hz
of Russian Academy of Sciences, Pushchino, Moscow Region, in young typically developing children and children
Russia; Institute of Medical Psychology, Faculty of Medicine, with autism spectrum disorder (2020)
University Hospital Frankfurt, Goethe University, Frankfurt
am Main, Germany; University of Koblenz-Landau, Landau Ono, Yasuki; Kudoh, Kiwamu; Ikeda, Takashi; Takahashi,
(Pfalz), Germany; Campus Institute for Dynamics of Biologi- Tetsuya; Yoshimura, Yuko; Minabe, Yoshio; Kikuchi,
cal Networks, Georg-August University, Goettingen, Germany; Mitsuru
School of Applied Psychology, University College Cork, Cork,
Ireland Department of Psychiatry and Neurobiology, Graduate
School of Medical Science, Kanazawa University, Kanazawa,
ABSTRACT In Autism Spectrum Disorders (ASD), Japan; Ricoh Company, Ltd, Kanazawa, Japan; Research
impaired response inhibition and lack of adaptation Center for Child Mental Development, Kanazawa University,
are hypothesized to underlie core ASD symptoms, such Kanazawa, Japan; Department of Neuropsychiatry, Faculty
as social communication and repetitive, stereotyped of Medical Science, University of Fukui, Kanazawa, Japan
behavior. Thus, the aim of the present study was to
compare neural correlates of inhibition, post-error AIM The early detection of autistic tendencies in
adaptation, and reaction time variability in ASD and children is essential for providing proper care and
neuro-typical control (NTC) participants by investigat- education. The auditory steady-state response (ASSR)
ing possible differences in error-related changes of provides a passive, non-invasive technique for assess-
oscillatory MEG activity. Twelve male NTC (mean age ing neural synchrony at specific response frequencies
20.3 ± 3.7) and fourteen male patients with ASD (mean in many mental disorders, including autism spectrum
age 17.8 ± 2.9) were included in the analysis. Subjects disorder (ASD), but few studies have investigated its
with ASD showed increased error-related reaction time use in young children. This study investigated the ASSR
variability. MEG analysis revealed decreased beta power at 20 Hz and 40 Hz in typically developing (TD) children
in the ASD group in comparison to the NTC group over and children with ASD aged 5-7 years.
the centro-parietal channels in both, the pre-stimulus
and post-response interval. In the ASD group, mean METHODS The participants were 23 children with ASD
centro-parietal beta power negatively correlated with and 32 TD children aged 5-7 years. Using a custom-
dimensional autism symptoms. In both groups, false made magnetoencephalography device, we measured
alarms were followed by an early increase in temporo- ASSR at 20 Hz and 40 Hz, compared the results be-
frontal theta to alpha power; and by a later decrease in tween groups, and evaluated the association with intel-
alpha to beta power at central and posterior sensors. lectual function as measured by Kaufmann Assessment
Single trial correlations were additionally studied in Battery for Children.
the ASD group, who showed a positive correlation of
pre-stimulus beta power with post-response theta, RESULTS Responses to 20 Hz and 40 Hz were clearly
alpha, and beta power, particularly after hit trials. On detected in both groups with no significant difference
a broader scale, the results deliver important insights identified. Consistent with previous findings, right
into top-down control deficits that may relate to core dominance of the 40-Hz ASSR was observed in both
symptoms observed in ASD. groups. In the TD children, the right-side 40-Hz ASSR

 ontents  Index 33
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