Page 51 - MEGIN Book Of Abstracts - 2023

and potential relevance for early detection of risk for with auditory radiation fractional anisotropy and age
autism. as independent variables was able to predict 52% of
M50 latency variance in TD children, but only 12%
Keywords: Autism, GSR, Habituation, Hypersensitivities, of variance in ASD. The ASD group exhibited altered
MEG patterns of M50 latency modulation characterized by
both higher variance and deviation from the expected
Journal of autism and developmental disorders (2021), structure-function relationship established with the TD
Vol. 51, No. 7 (32926307) (3 citations) group. The TD M50 latency model was used to identify
a subpopulation of ASD who are significant "outliers" to
the TD model. The ASD outlier group exhibited unex-
A Multimodal Study of the Contributions of pectedly long M50 latencies in conjunction with signifi-
Conduction Velocity to the Auditory Evoked cantly lower GABA levels. These findings indicate the
Neuromagnetic Response: Anomalies in Autism dependence of electrophysiologic sensory response
Spectrum Disorder (2020) latency on underlying microstructure (white matter)
and neurochemistry (synaptic activity). This study
Roberts, Timothy P L; Bloy, Luke; Ku, Matt; Blaskey, Lisa; demonstrates the use of biologically based measures
Jackel, Carissa R; Edgar, James Christopher; Berman, to stratify ASD according to their brain-level "building
Jeffrey I blocks" as an alternative to their behavioral phenotype.
LAY SUMMARY: Children with ASD often have a slower
Department of Radiology, Perelman School of Medicine, brain response when hearing sounds. This study used
University of Pennsylvania, Philadelphia, Pennsylvania, USA; multiple brain imaging techniques to examine the
Department of Radiology, Lurie Family Foundations MEG structural and neurochemical factors which control
Imaging Center, Children's Hospital of Philadelphia, Philadel- the brain's response time to auditory tones in children
phia, Pennsylvania, USA; Department of Child and Adoles- with ASD and TD children. The relationship between
cent Psychiatry and Behavioral Sciences, Center for Autism brain imaging measures and brain response time was
Research, The Children's Hospital of Philadelphia, Philadel- also used to identify ASD subgroups. Autism Res 2020,
phia, Pennsylvania, USA; Division of Developmental and 13: 1730-1745. © 2020 International Society for Autism
Behavioral Pediatrics, The Children's Hospital of Philadelphia, Research and Wiley Periodicals LLC.
Philadelphia, Pennsylvania, USA
Keywords: MR spectroscopy, autism spectrum disorder,
ABSTRACT This multimodal imaging study used mag- conduction velocity, diffusion MRI, magnetoencephalog-
netoencephalography, diffusion magnetic resonance raphy, multimodal imaging
imaging (MRI), and gamma-aminobutyric acid (GABA)
magnetic resonance spectroscopy (MRS) to identify Autism research: official journal of the International
and contrast the multiple physiological mechanisms Society for Autism Research (2020), Vol. 13, No. 10
associated with auditory processing efficiency in (32924333) (8 citations)
typically developing (TD) children and children with
autism spectrum disorder (ASD). Efficient transmission
of auditory input between the ear and auditory cortex Markers for the central serotonin system correlate
is necessary for rapid encoding of auditory sensory to verbal ability and paralinguistic social voice
information. It was hypothesized that the M50 audi- processing in autism spectrum disorder (2020)
tory evoked response latency would be modulated
by white matter microstructure (indexed by diffusion Yoshimura, Yuko; Kikuchi, Mitsuru; Saito, Daisuke N;
MRI) and by tonic inhibition (indexed by GABA MRS). Hirosawa, Tetsu; Takahashi, Tetsuya; Munesue, Toshio;
Participants were 77 children diagnosed with ASD and Kosaka, Hirotaka; Naito, Nobushige; Ouchi, Yasuomi;
40 TD controls aged 7-17 years. A model of M50 latency Minabe, Yoshio

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