Page 60 - MEGIN Book Of Abstracts - 2023

accurate brain-based diagnosis for the highly misdiag- methodological heterogeneity and an overall high risk
nosed MDD/BD patients. of bias. Patients with bipolar disorder showed consis-
tent reductions in 40-Hz ASSR evoked power (Hedges'
Annual International Conference of the IEEE Engineering g = -0.49; 95% confidence intervals [-0.67, -0.31]) and
in Medicine and Biology Society. IEEE Engineering in inter-trial phase coherence (ITPC) (Hedges' g = -0.43;
Medicine and Biology Society. Annual International 95 %CI [-0.58, -0.29]) compared with healthy controls.
Conference (2022), Vol. 2022 (36086021) (0 citations)
CONCLUSIONS Our meta-analysis provides evidence
that 40-Hz ASSRs are reduced in patients with bipolar
The 40-Hz auditory steady-state response in bipolar disorder compared with healthy controls.
disorder: A meta-analysis (2022)
SIGNIFICANCE Future large-scale studies are warrant-
Jefsen, Oskar Hougaard; Shtyrov, Yury; Larsen, Kit ed to link 40-Hz ASSR deficits to clinical features and
Melissa; Dietz, Martin J developmental trajectories.

Psychosis Research Unit, Aarhus University Hospital - Psy- Keywords: Bipolar disorder, Electroencephalography,
chiatry, Aarhus, Denmark; Center of Functionally Integrative Gamma rhythm, Magnetoencephalography, Meta-analy-
Neuroscience, Department of Clinical Medicine, Aarhus Uni- sis, Systematic review
versity, Aarhus, Denmark. Electronic address: [email protected];
Danish Research Centre for Magnetic Resonance, Centre for Clinical neurophysiology: official journal of the
Functional and Diagnostic Imaging and Research, Copen- International Federation of Clinical Neurophysiology
hagen University Hospital - Amager and Hvidovre, Copenha- (2022), Vol. 141 (35853310) (2 citations)
gen, Denmark; Child and Adolescent Mental Health Centre,
Copenhagen University Hospital, Mental Health Services,
Capital Region Psychiatry, Copenhagen, Denmark Differences in verbal and spatial working memory
in patients with bipolar II and unipolar depression:
OBJECTIVE Bipolar disorder is characterized by aber- an MSI study (2021)
rant neurophysiological responses as measured with
electroencephalography (EEG) and magnetoencepha- Li, Zhinan; Chen, Junhao; Feng, Yigang; Zhong,
lography (MEG), including the 40-Hz auditory steady- Shuming; Tian, Shui; Dai, Zhongpeng; Lu, Qing; Guan,
state response (ASSR). 40-Hz ASSR deficits are also Yufang; Shan, Yanyan; Jia, Yanbin
found in patients with schizophrenia and may repre-
sent a transdiagnostic biomarker of neuronal circuit Psychiatric Department, The Third Affiliated Hospital of Sun
dysfunction. In this systematic review and meta-analy- Yat-sen University, Guangzhou, China; Psychiatric Depart-
sis, we summarize and evaluate the evidence for 40-Hz ment, The First Affiliated Hospital of Jinan University, 613
ASSR deficits in patients with bipolar disorder. West Huangpu Avenue, Guangzhou, 510630, China; Depart-
ment of Electrophysiology, the Guangdong 999 brain Hospi-
METHODS We identified studies from PubMed, tal, Guangzhou, China; Key Laboratory of Child Development
EMBASE, and SCOPUS. We assessed the risk of bias, cal- and Learning Science, Southeast University, Nanjing, China;
culated Hedges' g meta-level effect sizes, and investi- Psychiatric Department, The First Affiliated Hospital of Jinan
gated small-study effects using funnel plots and Egger University, 613 West Huangpu Avenue, Guangzhou, 510630,
regression. China. [email protected]

RESULTS Seven studies, comprising 396 patients BACKGROUND Depressive symptoms could be simi-
with bipolar disorder and 404 healthy controls, were larly expressed in bipolar and unipolar disorder. How-
included in the meta-analysis. Studies displayed ever, changes in cognition and brain networks might

 ontents  Index 39
C