Page 63 - MEGIN Book Of Abstracts - 2023

Julie J; Gerstner, Elizabeth R; Stufflebeam, Steven M; First, correlation coefficients were calculated between
Hillebrand, Arjan; Stam, Cornelis J; Geurts, Jeroen J G; group-level regional glioma occurrence, as obtained
Reijneveld, Jaap C; Douw, Linda by concatenating tumour masks across patients, and
group-averaged regional intrinsic brain activity. Sec-
Amsterdam Neuroscience, Brain Imaging, Amsterdam 1081 ond, intrinsic brain activity at specific tumour locations
HV, The Netherlands; Department of Medical Psychology, was calculated by overlaying patients' individual tu-
Amsterdam UMC location Vrije Universiteit Amsterdam, mour masks with regional intrinsic brain activity of the
Amsterdam 1081 HV, The Netherlands; Department of controls and was associated with tumour and patient
Neurosurgery, Amsterdam UMC location Vrije Universiteit characteristics. As proposed, glioma preferentially oc-
Amsterdam, Amsterdam 1081 HV, The Netherlands; Depart- curred in brain regions characterized by higher intrinsic
ment of Neurology, Harvard Medical School, Massachusetts brain activity in controls as reflected by higher offset.
General Hospital, Boston, MA 02114, USA; Athinoula A. Second, intrinsic brain activity at patients' individual
Martinos Center for Biomedical Imaging, Massachusetts tumour locations differed according to glioma subtype
General Hospital, Charlestown, MA 02129, USA; Department and performance status: the most malignant isocitrate
of Clinical Neurophysiology and MEG Center, Amsterdam dehydrogenase-wild-type glioblastoma patients had
UMC location Vrije Universiteit Amsterdam, Amsterdam the lowest excitation/inhibition ratio at their individual
1081 HV, The Netherlands; Department of Anatomy and tumour locations as compared to isocitrate dehydroge-
Neurosciences, Amsterdam UMC location Vrije Universiteit nase-mutant, 1p/19q-codeleted glioma patients, while
Amsterdam, Amsterdam 1081 HV, The Netherlands; Depart- a lower excitation/inhibition ratio related to poorer
ment of Neurology, Stichting Epilepsie Instellingen Nederland, Karnofsky Performance Status, particularly in codeleted
Heemstede 2103 SW, The Netherlands glioma patients. In conclusion, gliomas more frequently
occur in cortical brain regions with intrinsically higher
ABSTRACT It is unclear why exactly gliomas show activity levels, suggesting that more active regions are
preferential occurrence in certain brain areas. Increased more vulnerable to glioma development. Moreover,
spiking activity around gliomas leads to faster tumour indices of healthy, intrinsic excitation/inhibition ratio
growth in animal models, while higher non-invasively at patients' individual tumour locations may capture
measured brain activity is related to shorter survival in both tumour biology and patients' performance status.
patients. However, it is unknown how regional intrinsic These findings contribute to our understanding of
brain activity, as measured in healthy controls, relates the complex and bidirectional relationship between
to glioma occurrence. We first investigated whether gli- normal brain functioning and glioma growth, which is
omas occur more frequently in regions with intrinsically at the core of the relatively new field of 'cancer neuro-
higher brain activity. Second, we explored whether science'.
intrinsic cortical activity at individual patients' tumour
locations relates to tumour and patient characteris- Keywords: cancer neuroscience, magnetoencephalog-
tics. Across three cross-sectional cohorts, 413 patients raphy, network neuroscience, neuro-oncology, primary
were included. Individual tumour masks were created. brain tumours
Intrinsic regional brain activity was assessed through
resting-state magnetoencephalography acquired in Brain: a journal of neurology (2022), Vol. 145, No. 10
healthy controls and source-localized to 210 cortical (36130310) (1 citation)
brain regions. Brain activity was operationalized as: (i)
broadband power; and (ii) offset of the aperiodic com-
ponent of the power spectrum, which both reflect neu- Non-invasively measured brain activity and
ronal spiking of the underlying neuronal population. radiological progression in diffuse glioma (2021)
We additionally assessed (iii) the slope of the aperiodic
component of the power spectrum, which is thought Numan, T; Kulik, S D; Moraal, B; Reijneveld, J C; Stam,
to reflect the neuronal excitation/inhibition ratio. C J; de Witt Hamer, P C; Derks, J; Bruynzeel, A M E; van

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C